Objective   To analyse changes of cerebrovascular hemody mamic indexes (CVHI) in high risk population of stroke before and after intervention and provide reference for stroke primary prevention.

  Methods   Target populations over 35 years were selected by cluster sampling from Sandun, Wangxiang and Shuyan Town in Nanhui County of Shanghai.6 170 persons with exposure of risk factor of stroke, such as hypertension, diabetes, heart disease, family history of stroke or hypertension, were selected from 36972 target populations. Examination of CVHI were carried out during baseline investigation and 999 persons whose CVHI score below 70 points were divided into two groups according to personal wish. One group received Chinese medicine named Nao an Capsule based on general intervention, and the other only received general intervention. CVHI score and single indexes were compared before and after three-year intervention.

  Results   CVHI score before and after general intervention were 49.7±18.8 and 73.4±26.6, and improved by 47.7 percent. The score before and after Naoan Capsule intervention were 41.3±19.8 and 71.1±26.1, and improved by 72.2 percent. CVHI, such as Vmin, Vmax, Vmean were significantly increased after intervention in both groups. However, Rv, WV, Zcv, DR and CP were obviously decreased. Range of CVHI in Naoan capsule intervention group were more significant than that in general intervention group.

  Conclusion   CVHI score as well as single index were significantly improved after intervention and the Naoan capsule intervention was more effective. The intervention measures could obviously improve cerebral vascular function.