复方马齿苋对大鼠红细胞膜流动性等的影响

贺圣文; 赵仁宏; 王守训; 陈景武; 李寿花; 李桂芝

复方马齿苋对大鼠红细胞膜流动性等的影响

Effects of compound purslare on rat's RBC membrane fluidity and so on

摘要

摘要:
目的研究马齿苋与其它降血脂药物或成分如何合理组方联用, 以便寻找最佳降血脂方案。
方法选用有重复的正交试验设计, 观察3个因素、2个水平及各因素间的一级交互作用, 根据正交表L₈(2⁷)安排试验因素, 分析复方马齿苋(A)、复方微量元素(B)、复方决明子(C)对高脂血症等的防治作用。
结果红细胞膜流动性等8个指标3个因素A间、B间、C间, 有显著性差异(P < 0.01或0.05), A₂ > A₁, B₂ > B₁, C₂ > C₁, A、B、C同时应用效果最好, 且作用A优于C优于B, 最优组合为A₂C₂B₂(P < 0.01或0.05)。
结论复方马齿苋及其组合皆能阻止血清总胆固醇(TC)、载脂蛋白B(apoB)、血小板聚集率、红细胞膜流动性微粘度数值、红细胞刚性指数(IR)升高, 提高载脂蛋白A1(apoA₁)、谷胱甘肽过氧化酶(GSH-Px)、卵磷脂胆固醇酰基转移酶(LCAT)水平; 马齿苋与其它降血脂药物或成分合理组合使用, 发挥多因素的协同作用, 其效果更佳。

Abstract:
Objective To explore purslane with other durgsor compositions how to be combined to lower blood lipids. To find out the best combintion for preventing and treating.
Methods Using orthogonal test design to analyse anti-hyperlipidemia effect of compound purslane(A), compound microelement(B)and compound juemingzi (C).
Results 8 indexes like RBC membrane fluidity, etc of A, B and C had statistical significance(P < 0.01 or 0.05);while A, C, B were used simultaneously, the effect was the best; and the effect was A > C > B. The best combination was A₂C₂B₂(P < 0.01 or 0.05).
Conclusion Compound purslane with it's combination could decrease TC, apolipoprotein B (apoB), platelet aggregation rate, RBC membrane fluidity micro-viscosity, RBC IR as well and increase apoA1, GSH-Px, LCAT.By combination, the effect of purslane was better.

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