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王洪军, 王桂君, 胡晓芳, 孙华, 王立强, 赵雪俭. 前列腺几种生化组分与前列腺癌的关系[J]. 中国公共卫生, 2003, 19(2): 148-149.
引用本文: 王洪军, 王桂君, 胡晓芳, 孙华, 王立强, 赵雪俭. 前列腺几种生化组分与前列腺癌的关系[J]. 中国公共卫生, 2003, 19(2): 148-149.
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WANG Hong-jun, WANG Gui-jun, HU Xiao-fang, . Relation between TGFβ1、EGF、P53、PCNA and prostatic cancer[J]. Chinese Journal of Public Health, 2003, 19(2): 148-149.
Citation: WANG Hong-jun, WANG Gui-jun, HU Xiao-fang, . Relation between TGFβ1、EGF、P53、PCNA and prostatic cancer[J]. Chinese Journal of Public Health, 2003, 19(2): 148-149.
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前列腺几种生化组分与前列腺癌的关系

Relation between TGFβ1、EGF、P53、PCNA and prostatic cancer

    摘要
  • 摘要:
      目的   以7所医院近5年来前列腺癌手术与组织活检为样本, 研究TGFβ1、EGF、P53及PCNA与前列腺癌发生发展的内在规律。
      方法   通过免疫组化的方法对36例患者进行定位、定性分析。
      结果   TGFβ1、EGF在前列腺癌组织中其腺上皮的癌细胞的胞浆、胞核与周围基质呈阳性达80%以上, P53及PCNA使癌细胞的胞核染色呈强阳性, 胞浆染色弱阳性约占60%。
      结论   TGFβ1、EGF是基质和上皮相互作用信号传导通路的重要组成部分, 与前列腺癌的病因及异常生长具有相关性。P53与PCNA阳性染色, 说明P53蛋白基因发生突变与癌细胞增殖活跃。

     

    Abstract:
      Objective   To sutdy the cause and effect relation between TGFβ1、EGF、P53、PCNA and prostatic cancer.Samples came from surgical operation and tissues biopsy.
      Methods   Thirty-six patients with prostatic cancer were analyzed and explored by immunohistochemistry.
      Results   It was stronger positive(> 80%)for the cell nucleus and cell thick liquid of cancer cell as well as surrounding matrix in prostatic cancer tissues.Expression of P53 in prostatic cancer tissues was also observed with antibodies against them.Positive stain of P53 was found both in nuclei and cytoplasm of epithelium cells in prostatic cancer tissues.Innumoposit ive stain of PCNA was presented in prostatic cancer cell(> 60%).
      Conclusion   Mutation of P53 occurred in prostatic cancer tissues and reflected actively proliferative capacity and status of cancer cells.

     

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