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宋扬, 刘国荣, 杜卫. 复合膳食纤维对大鼠降脂效果观察[J]. 中国公共卫生, 2003, 19(2): 156-158.
引用本文: 宋扬, 刘国荣, 杜卫. 复合膳食纤维对大鼠降脂效果观察[J]. 中国公共卫生, 2003, 19(2): 156-158.
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SONG Yang, LIU Guo-rong, DU Wei. Preparation of fiber complexes and its role in prevention of atherosclerosis[J]. Chinese Journal of Public Health, 2003, 19(2): 156-158.
Citation: SONG Yang, LIU Guo-rong, DU Wei. Preparation of fiber complexes and its role in prevention of atherosclerosis[J]. Chinese Journal of Public Health, 2003, 19(2): 156-158.
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复合膳食纤维对大鼠降脂效果观察

Preparation of fiber complexes and its role in prevention of atherosclerosis

    摘要
  • 摘要:
      目的   制备复合膳食纤维(dietaryfiber, DF), 并探讨其与3种单一的DF对高脂血症大鼠体内脂类含量的影响。
      方法   健康、雌性、断乳Wistar大鼠48只, 按体重随机分为6组, 用高脂饲料诱发高酯血症的同时, 分别添加10%的DF: 纤维素(B组)、果胶(C组)、海藻酸钠(D组)、纤维素-果胶复合物(E组)、纤维素-海藻酸钠复合物(F组), 以单纯的高脂饲料组为对照组(A组), 8周后观察各种DF对大鼠的生长发育及脂类代谢的影响。
      结果   (1) 添加10%的各种DF不影响大鼠的生长发育。(2)与对照组比, 各种DF皆可不同程度降低大鼠脂质水平, 且以复合物效果为佳。(3)各种DF可不同程度地增加粪重和粪酯排出量(P < 0.05, D组除外), 以复合物为明显。(4)相关分析显示, 血清TC、TG、LDL-C含量与粪脂含量呈负相关(P < 0.01)。
      结论   各种DF皆可不同程度地降低大鼠体内脂类含量, 其中可溶性DF效果优于不可溶性DF, 而复合DF的效果又优于单一的DF。

     

    Abstract:
      Objective   To prepare the artificial fiber complexes and examine its role in lipid content in comparison with other three single fibers in hyper lipidemia rats.
      Methods   Forty-eighthealthy, female Wistar rats(50-80g)were randomly divided into six groups based on body weight.All five kinds of DF(cellulose-group B, pectin-group C, sodium alginategroup D, cellulose-pectin complex-group E, cellulose-sodium alginate complex-group F)were given at a level of 10% in the diet fed on a lipid-rich diet.The control group(group A)was fed on a lipid-rich diet alone without DF.A fter eight weeks, the effect on growth and development and lipid metabolism in rats were studied.
      Results   (1) Five kinds o f DF did not affect the growth and development of the expreimental rats.(2)Compared with the control group, all DF groups can lower lipids, especrial fiber complexes.(3)The fecal weight and fat contents in all DF groups were significantly higher than that in control group, especially for fiber complex groups.(4)There were obviously correlation between serum lipids and fecal fat contents.
      Conclusion   These kinds of DF had the effect of lowering lipids to so me extent in rats, and fiber complexes were more effective than single fibers.

     

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