硒拮抗砷致大鼠血脂谱改变的效应特征研究

李建国; 杨瑾; 刘志艳; 梁维萍; 李金友

硒拮抗砷致大鼠血脂谱改变的效应特征研究

Antagonistic effect of selenium on arsenic-induced changes in blood lipids spectrum in rat

摘要

摘要:
目的明确硒拮抗砷致大鼠血脂谱变化的可行性及剂量特征。
方法将受试动物随机分为阴性对照组、砷组、硒组及砷+硒组(以测试物的LD₅₀为剂量划分依据).染毒后测定血中血脂含量的变化。
结果与阴性对照组比较, 1/5LD₅₀As组血中总胆固醇、甘油三酯和高密度脂蛋白含量均有显著性差异(P < 0.05), 总胆固醇和甘油三酯呈下降趋势, 高密度脂蛋白呈上升趋势: 与1/5LD₅₀As相比, 1/5LD₅₀As+1/160LD₅₀Se组血中甘油三酯含量有显著性差异(P < 0.05);1/5LD₅₀As+1/120LD₅₀Se组血中总胆固醇、甘油三酯含量有显著性差异(P < 0.05);1/5LD₅₀As+1/80LD₅₀Se组血中总胆固醇、甘油三酯和高密度脂蛋白含量均有显著性差异(P < 0.05)。
结论结果提示, 砷可致大鼠血脂谱的改变, 硒对其具有拮抗作用, 且以1/80LD₅₀Se组拮抗效果较好。

Abstract:
Objective To clarify the feasibility of seleniumag ainstarsenic-induced blood lipids changes in rat and its dose range characteristics.
Methods The rats were randomly divided into control, arsenic, selenium, arsenic and selenium in combination, respetively.A fter various treatments, the blood lipids were determined.
Results In comparison with the levels of total cholesterol(TC), trig lyceride(TG)and high-density lipoprotein(HDL)in control group, there was a significant decrease in TC and TG and arise in HDL in 1/5 LD₅₀ arsenic group.Relative to those in 1/5 LD₅₀ arsenic group, there was a significant difference in TG in 1/5 LD₅₀ As and 1/160 LD₅₀ Se group(P < 0.05), TC and TG in 1/5 LD₅₀ As and 1/120 LD₅₀ Se group(P < 0105).TC, TG and HDL in 1/5 LD₅₀ As and 1/80 LD₅₀ Se group(P < 0.05), respectively.
Conclusion Arsenic could induce a change in blood lipids spectrum in rat and that selenium could combatagainst this change.1/80 LD₅₀ Se might be the optimal dose for the effect.

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