对二氯苯对实验性变态反应性结膜炎的影响

Effects of paradichlorobenzene on experimental allergic conjunctivitis

摘要:
目的探讨对二氯苯(Paradichlorobenzen, p-DCB)对变态反应性结膜炎的影响。
方法采用杉木花粉抗血清免疫豚鼠复制实验性变态反应性结膜炎模型, 并定量检测结膜炎轻重, 观察不同浓度对二氯苯对其病情变化的影响。
结果空气中对二氯苯浓度仅为41μg/m³时就对变态反应性结膜炎有增强作用。41μg/m³时增强作用最明显.其增强作用持续1周以上。
结论对二氯苯具有一定免疫毒性, 低浓度时能明显加重变态反应性结膜炎。

Abstract:
Objective To study the effect of paradichlorobenzene on the allergic conjunctivitis.
Methods The effects of different concentrations of paradichlorobenzene were observed by quantitatively measuring the conjunctivitis, which was based on the model of anti-cedar-pollen serum induced allergic conjunctivit is in guinea pigs.
Results The allergic conjunctivitis was apparently aggr avated when the concentration of paradichlorobenzene was over 4.1 μg/m³ in the air, and most intensive aggravating effect was obtained at a dosage of 41 μg/m³ paradichlorobenzene, which persisted for more than 1 week.
Conclusion The paradichlorobenzene had the effect of immunotoxicity, and apparently agg ravated allergic conjunctivitis at lower concentration.