富硒板党对小鼠益智和低氧/复氧损伤的保护

肖本见; 谭志鑫; 陈国栋; 李玉山

富硒板党对小鼠益智和低氧/复氧损伤的保护

Protective effect of rich selenium-banqiao-codonopsis pilosula on intelligence development and hypoxia/reoxygenation injury in mice

摘要

摘要:
目的探讨富硒板党对小鼠益智和低氧/复氧损伤的保护作用.
方法益智实验采用苯异丙腺甘(PIA)致小鼠学习记忆障碍等益智模型; 抗氧化实验采用小鼠低氧/复氧损伤的模型, 检测小鼠血液中活性氧(ROS)、过氧化氢酶(CAT)、超氧化物歧化酶(SOD)和丙二醛(MDA)值.
结果富硒板党水煎液可提高小鼠的学习记忆能力, 明显延长小鼠游泳时间; 降低ROS和MDA值, 增强SOD活性, 对CAT作用不明显.
结论富硒板党对小鼠具有益智和低氧/复氧损伤的保护作用.

Abstract:
Objective To Study on promoting intelligence developmenteffects and preventing hy poxia/reox ygenation injury of rich selenium-banqiao-codonopsis pilosula in mice.
Methods Learning and memory barrier model induced by phenylisopropyladenosine(PIA) was adopted in promoting intelligence develo pmentexperiment; and anti-oxygenaion experimentmice hy poxia/reoxy genation injury model was used to measure the activity of reactire oxy gen species(ROS), calalase(CAT), superoxide dismutase(SOD)and malondialdehy de(MDA)in blood.
Results Rich selenium-danqiao-codonopsis pilosula boild water could enhance the learning and memory ability of mice; obviouslyextend the swimming time of mice; could decrease the quality of ROS and MDA; increase the activity of SOD, butithad no obvious effecton CAT.
Conclusion Rich selenium-banqiao-codonopsis pilosula had effects of promoting intellig ence developmentand preventing gypoxia/reox ygenation injury.

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