钙蛋白酶10基因多态性与2型糖尿病遗传性

龚鹤琴; 张茂镕; 邱俊; 李云涛; 鄢志梅; 杨昭; 沈庆辉; 马景孚

钙蛋白酶10基因多态性与2型糖尿病遗传性

Correlation study of calpain 10 gene polymorphism with genetic susceptibility to type 2 diabets

摘要

摘要:
目的探讨昆明高原地区钙蛋白酶10基因(Calpain 10基因)单核苷酸多态性-SNP43与2型糖尿病遗传易感性的关系.
方法采用1:1病例对照研究方法, 在昆明市城市社区选取131名2型糖尿病患者和131名正常对照者.应用聚合酶链式反应双引物等位基因特异性扩增法(PCR-ASA)检测Calpain 10基因UCSNP43位点G/A等位基因的多态性.
结果 (1) UCSNP43的G等位基因频率及GG基因频率在2型糖尿病患者中均较对照组显著升高, 分别为93.13%和86.26%(P=0.009 7), 86.26%和73.28%(P=0.008 9).(2)SNP43位点的G/G基因型与2型糖尿病相关, 经Logistic回归分析, OR值在2型糖尿病患者为2.24, P=0.006.
结论 Calpain 10基因的SNP43位点与昆明人2型糖尿病的遗传易感性有关.

Abstract:
Objective To probe the association of single nucleotide polymorphism-SNP43 in Calpain 10 gene with genetic susceptibility to type 2 diabets in kunming plateau districts.
Methods The polymorphism of site UCSNP43(G/A)in Calpain 10 gene was detected by poly merase chain reaction and Allele specific amplification(PCR-ASA)in 131 type 2 diabetic patients and 131 non-diabetic controls who were selected using cas-econtrol study in the Kunming urban communities.
Results (1) The frequency of "G" allele and "GG" allele of site UCSNP43 in diabetic patients was significantly higher than thatin the controls.(2)Genotype of "GG" of site SNP43 was related with type 2 diabets, odd ratio was 2.24, P=0.006.
Conclusion Site SNP43 of Calpain 10 gene may be associated with genetic susceptibility to type 2 diabets in Kunming population.

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