Abstract: Selected 1 month old ICR strain of mice, were divided into four groups at random, then given by 1mg/L,5mg/L and 10 mg/L NaF solution and distilled water control group respectively eight weeks later; the influences of fluorosis on the capablit of lerrning memory behavior of mice were assessedby using Open-field and Y-maze, 10 weeks later, the influence of fluorosios on the physical stain ina of mice were investigated The resuLts showed (1) the numberer of rearing and ambulation in middle and hight fluoride groups were low ere than Con trol and low fluorIDe groups the most fluoride groupS variety was the high;(2)with fluoride density increasing, darning ability ofmice presented marked deterioration(P<0.05 compared hwight fluoride group with control group, fhxorosis had no conificant effect on memory retention (3) in the physical stamina swimm ing, the middle and hIGHt fLUoride groupS drow ned aftera shorter period of time than the low fluoride (P<0.05 and P<0.01. All the results suggest that fluorosis had significantinfluences on the some open-field behavior the capacity oflearnine and nhv sical stanina of mice.