Abstract: Mices were dived into four groups including 50 1000mg VEO per kg diet groups and fed for 8 week to evaluate the effects of vitan in E on differentiation of Tlylnphocryte specific subgroups in thymus and IL-1 production by ciliac 1naPIDphage The results showpal that there were significant incease in the percentage of T cell Th subgroup Th/Ts can do and decrease in TSsubgroup in vitamin E supphn ental groups IG-IP mduction by celiac macrophage was enhanced follow ing vitaln in E supp lan ent In above tes is it had the stronger reaction in three tines requiranent group than in twenty times requ iran en t group and had a trend to decline following high dose vitan in E supplement but no impair reaction was founded.