Abstract: The cause of Congenital H east Disease（CHD)roanairl unknown To test the effect of m aternalm ental-stress during early pregnancy on the occurence CHD in the off spring 351 pairs of matched cases and controls were studid Datawere derived frcxn CH D general investigation of children aged 0-2years in ZheJiang Province The results show ed thatm atemal mental-stress during early pregnancry may increase the occur rence risk of CHD in the o ffspring the odds ratio and the 95% confxlence interval are 9.43 and 2543~6188 respeetvely To lower the risk of CHD occurrence it's in protant for newly-rnarriedw cxnen to have a happy mood during early pregnacy.