Abstract: Simple and sensitive chromosome damage iadices iacludiag inductioa of chromosomal aberrations in germ cells of testis and sperm abnormalities is mice were used to study the of sodium fluoride. The results showed that no sigaificant mutatioa production was found at expourse level (1.4mg/kg), while sigaificeat damage in male germ cells and iaterference of spermatogeaesis were observed in mice exposed to higher doses(7.0, 28.0mg/kg).