Abstract: The infection of CMV is very common, but the prevalence and the Level of antibody to CMV in population have not been reported Yet in our country. We estaulished ELISA method is which purified CMV was used as coating antigen for detection of anti-CMV IgG.285 sera from normal persons in Zhending county of Hebei province were tested. The results showed that the positive rate of antibody to CMV was 56% in 1-5 Years old group and reached 100% in persons over 50 Years of age, indicating increase is rate of CMV infection along with age.