Abstract: In order to realize immune state of the children who lived in different polluted env ironment of Guiyang area. 265 samples of the children. salive were collected; 92 of those liv ed in enviroment of industr ial pollution: 90 of those lived in the centre of Guiyang city; 83 of those lived in the countryside of the city. Content of lysozyme and SIgA in every sample were determined by slab pinhole ELISA and simple agar diffusion. The results showed that content of lysozyme and SIgA in the salive of the children who lived in environment of industrial pollution and centre of the city was lower obviously than that of children who lived the countryside of the city by stat istics ways. It proved that immune level of children were reduced obviously by different pollution.