国产酵母重组乙肝疫苗不同免疫程序免疫的效果观察

A comparative efficacy trial of different schedules of immunization with a recombinanat yeast derived hepatitis B vaccine

摘要: 应用2批国产酵母重组乙肝疫苗,分别按0、1、2、和0、1、6免疫程序对393名小学生进行1年免疫效果观察。所有接种的小学生中未发现严重副反应者。结果表明,免疫程序对抗体阳转率影响较小,第1针免疫后3个月(T3)时,接种各疫苗组的抗体阳转率均达或接近90%,第1针免疫后7个月(T7)时,接种各疫苗组的抗体阳转率均达高峰(90.00%～98.28%),其后开始缓慢下降,而抗体GMT与免疫程序有关,0、1、2免疫程序组抗体GMT上升快,而0、1、6组抗体峰值高。

Abstract: In order to evaluate the safety and immunogenicity of 0、1、2 and 0、1、6 schedules with a recombinanat yeast derived hepattitis B vaccine(YDV),two batches of YDV produced by National Vaccine and Serum Institute Products(5ug/dose)were administered to 393 school children.No serious side effects were found.At the third month after the first dose(T3),the anti-HBs positive rates of all groups were above 88% and reached the peak at the seventh month(T7),and declineds lowly afterwards.The GMT of 0、1、2 schedule in both batches were significantly higher than at T3,but much lower at T7,as compared with 0、1、6 schedule.