慢性阻塞性肺部疾病遗传流行病学的初步分析

Genetic epidemiology analysis of chronic obstructive pulmonary disease

摘要: 为了探讨遗传因素与慢性阻塞性肺部疾病(COPD)之间的关系,进一步提高人们对COPD的环境病因和遗传病因的认识,收集了206个COPD核心家系的资料?分析结果表明,COPD的分离比为0.27,COPD属于多基因遗传;COPD的遗传度为44.4%,其中男性为49.3%,女性为38.8%?显示遗传因素在男性产生COPD的过程中作用较大;但不论男性还是女性发生COPD,遗传因素和环境因素,同样都是COPD发病的重要危险因素?

Abstract: To determine the relation between genetic factor and chronic obstructive pulmonary disease(COPD).we selected 206 COPD nuclear families and 206 contml nuslear fanilies. The data of those families were analysed. The segregation redo of COPD was 0.27 and the genetic model of COPD belonged to polygenetics.Theheritability of COPD was 44.4%,49. 3% for male and 38.8% for female. It is coneluded that genetic factor as the environmental factors is one of the risk factors for copd,and is specially of imporrance for males.