Abstract: The purose of this report was to observe and analyse Immunological effects of the two types of inactivated vaccines against HFRS.The mongolian gerbils kidney vaccine (Type I) was used in Dawa County the hamsper kidney vaccine (Type II) was used in Huludao City.We collected blood samples before and after basic immunization before and after reimmunization,on the third and fouthyear after the reimmunization,using IFAT and MCPENT techniques to detect fluorecent and neutralizing antibodies.The result indicates that for Type I vaccine the positive rate of IFA antibody is 6.2% (subclinical infection) 100%.54.9%.100%,77.4%,72.0% respectively;the positive rate of neutralizing antibody is 0,70.4%,0,73.0%,32.3%,32.0% repectively.For Type II vaccine the positive rate of IFA antibody is 9.9%(sub-clinical infection) 100%,36.4%,100%,77.1%,80 0% respectively;the positive rate of neutralizing antibody is 0,50%,18%,100%,51.4%,44%,respectively.Conclusion The two types of vaccines all have good protective action and persistence of antibodies.