Abstract: For studying the value of IgM capturing ELISA with recombinant antigen to the serodiagnosis of HFRS The ELISA was established with antigen expressed from 76118 strain S genome segment in E.coli.combining with polyclonal Ab against human tl chain and HRP-labeled monoclonal Ab against Hantavirus.The method was used to detect 610 sera of suspected HFRS pstients and the results were compared to that of Indirect Fluorescent As-syay.The coincidences of ELISA with IFAwere94.10% for positive sera 92 83% for negative and 93.61% for general the sensitivities of the ELISA were apparently higher than that of the IFA for the patients that within 5 days ill length.equal for that with 6 to 30 days ill length,and lower for that with 1month or longer ill length; the month distribution of positive found was ac-cod with the infection rule.This IgM capturing ELISA in much accurate to diagnose HFRS in early stage.