Abstract: Objective To explore influencing factors of smoking cessation among male smokers in Guangdong province,and to provide evidence for prevention and intervention of smoking. Methods A cross-sectional survey was conducted among 3 181 male residents selected from 21 cities in Guangdong province with proportional probability sampling and Kishgrid methods.The information on smoking and smoking cessation was collected with a questionnaire survey. Results The prevalence of current smoking and smoking cessation among male smokers was 56.1%and 11.9%,and only 8.1% of them had succeeded in smoking cessation.The average age of quiting smoking was 41.6 years and 56.3% of male smokers had quitted before 45 years old.Among the current smokers,13.9%tried to quit smoking and 10.3% of them attended to quit smoking in six months and 3.6%in more than six months.The rate of trying to quit smoking was 21.9%in the past 12 months. Results from multiple factors analyses identified age,the level of attitude,and the degree of smoking were inhibitor of smoking cessation and years of smoking and having chronic diseases were promoting factors. Conclusion The rate of smoking cessation is relatively low among male smokers in Guangdong province.The major influencing factors for smoking cessation are age,age of smoking,the history of chronic disease,the level of attitude,and the degree of smoking.