Abstract: Objective To explore the level of job satisfaction among village health personnel(VHP)and to analyze relevant factors of job satisfaction at Puan county,Guizhou province. Methods A cross-sectional survey was conducted with a self-administered questionnaire among 149 VHP in January 2010 at Puan county,Qianxi'nan autonomous prefecture of Buyi and Miao minorities,Guizhou province. Results The score of general job satisfaction was 3.44±0.62.The score of welfare and income,working condition,and job characteristics was 2.76±0.76,2.92±0.80,and 3.32±0.70,respectively, which were lower than the score of general job satisfaction(P<0.01).The general job satisfaction could be predicted by working load,training chance,position promotion,medical service compensation criterion,VHP medical insurance,village clinic medicine,and working performance,with the crude coefficients of 0.16,0.21,0.19,0.12,0.12,0.08,and 0.09 (P<0.01),respectively.Training chance,supervisor reward,social security,job fulfillment,income,and gender had obvious effects on the general job satisfaction,with the odds ratios of 32.48,31.70,8.20,5.72,5.55,and 4.32,respectively.The Cox and Snell R2 was 0.53 and the modelχ² was 112.26(P<0.01). Conclusion The level of general job satisfaction is low for VHP.The general job satisfaction is influenced by training chance,supervisor reward,social security,job fulfillment, income,and gender.