Abstract: Objective To observe the effect of different feeding on the rehabilitation of immune dysfunction in severely burned rats and to investigate the method of improving the rehabilitation of immune function of severe burn. Methods Totally 100 healthy Wistar rats were randomly divided into group A(n=30,burned and fed with medicinal feeding,group B(n=30,burned and fed with bouillon),group C(n=30,bured and fed normally),and group D(n=10,normal control). The rats in group D were sacrificeded after scalded at 37℃.At 3,7,14 day post the burn and 10 rats in group A,B and C were also sacrificed under the condition of asepsis to detect the amount of T lymphocyte subsets,the activity of natuual killer (NK)cells,the levels of IgA,IgG,IgM,C₃,C₄,and the concentration of secretory immunoglobulin A(sIgA). Results Compared with group A,B,and C,the amount of the CD₃⁺,CD₄⁺,CD₈⁺,the ratio of CD₄⁺/CD₈⁺,the levels of IgA,IgG, IgM,C₃,C₄,and the activity of NK cells of group D were significantly higher at 3,7,14 day post the burn((P<0.05 or P<0.01).Compared with group B and C,all the indexes of group A recovered fast(P<0.05 or P<0.01). Conclusion The Medicinal feeding can play an important role in improving the distribution of T lymphocyte,enhancing the activity of NK cells,promoting the secretion ability of of sIgA in intestines mucous membrane,and the levels of IgM,IgG,C₃,C₄ in rats with severe burn.