Objective  To analyze epidemiological characteristics of suspected adverse events following immunization (AEFI) among children in Kaifeng municipality (Kaifeng) of Henan province in 2015.

  Methods  The data on children with AEFI reported in Kaifeng during 2015 were collected. Descriptive epidemiological methods were adopted to analyze the incidents of AEFI.

  Results  The reported cases of AEFI distributed in almost all the administration regions (100.00% for county level and 97.97% for township level) in the year and more cases were reported in Shunhe Hui ethnic district (19.50%), Weishi county (17.03%), and Jinming district (13%). The majority of the reported AEFI cases were small children less than one year old (58.51%) and at the ages one to two years (29.10%). More AEFI cases were reported in August (23.22%) of the year. The proportion of the cases related to vaccination of attenuated Japanese encephalitis vaccine was the highest (23.22%). Nearly all the reported cases (95.67%) were categorized as general type of AEFI, with main clinical symptoms of fever (80.19%), local red and swollen (21.05%), and crying (10.53%).

  Conclusion  In Kaifeng municipality during 2105, the reported cases of AEFI were mainly small children less one year old; more cases were reported in summer and autumn season and general reaction was the major type of AEFI reported.