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李岩, 王芹, 张洁. HLA-DRB1、DQB1基因多态性与肾综合征出血热相关性研究[J]. 中国公共卫生, 2018, 34(2): 290-292. DOI: 10.11847/zgggws1115749
引用本文: 李岩, 王芹, 张洁. HLA-DRB1、DQB1基因多态性与肾综合征出血热相关性研究[J]. 中国公共卫生, 2018, 34(2): 290-292. DOI: 10.11847/zgggws1115749
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Yan LI, Qin WANG, Jie ZHANG. Correlation between HLA-DRB1 and DQB1 gene polymorphism and hemorrhagic fever with renal syndrome[J]. Chinese Journal of Public Health, 2018, 34(2): 290-292. DOI: 10.11847/zgggws1115749
Citation: Yan LI, Qin WANG, Jie ZHANG. Correlation between HLA-DRB1 and DQB1 gene polymorphism and hemorrhagic fever with renal syndrome[J]. Chinese Journal of Public Health, 2018, 34(2): 290-292. DOI: 10.11847/zgggws1115749
shu

HLA-DRB1、DQB1基因多态性与肾综合征出血热相关性研究

Correlation between HLA-DRB1 and DQB1 gene polymorphism and hemorrhagic fever with renal syndrome

    摘要
  • 摘要:
      目的  探讨HLA-DRB1、DQB1基因多态性与肾综合征出血热（HFRS）相关性。
      方法  选取2007 — 2016年辽宁省铁岭市辖区内医院收治的HFRS患者300例为研究组研究对象，另选取300名健康体检者为对照组研究对象；利用序列特异性引物 – 聚合酶链反应（PCR-SSP）技术检测2组的HLA-DRB1、HLA-DQB1基因分型，分别比较2组HLA-DRB1、HLA-DQB1基因频率(GF)，并计算相对危险率(RR)，采用Pearson线性相关分析HLA-DRB1、DQB1基因多态性与HFRS相关性。
      结果  研究组患者HLA-DRB1等位基因共可检测出12个基因位点，对照组HLA-DRB1等位基因共可检测出13个基因位点，且研究组HLA-DRB1*16 GF为8.0%，明显高于对照组GF的1.0%（RR = 6.60，χ2 = 4.39，P < 0.05）；2组其余HLA-DRB1等位基因GF差异无统计学意义（P > 0.05）；研究组DQB1各等位基因与对照组相比差异无统计学意义（P > 0.05）；Pearson线性相关分析结果显示，HLA-DRB1*16基因与流行性出血热呈正相关关系（OR = 2.014，95 % CI = 0.373～10.132，P<0.05），DRB1*10基因与HFRS呈正相关关系（OR = 2.273，95 % CI = 0.254～9.252，P < 0.05）。
      结论  HLA-DRB1*16、HLA-DRB1*16基因与HFRS呈正相关关系，HLA-DRB1*16、HLA-DRB1*10基因可能是HFRS易感基因之一，可能是HFRS发生中的危险因素。

     

    Abstract:
      Objective  To investigate the relationship between HLA-DRB1, DQB1 gene polymorphism and hemorrhagic fever with renal syndrome（HFRS).
      Methods  We recruited 300 HFRS patients taking medical services and 300 healthy persons having physical examinations as the controls at hospitals in Tieling municipality of Liaoning province between 2007 and 2016. PCR amplification with sequence-specific primers (PCR-SSP) was used to detect genotypes of HLA-DRB1 and HLA-DQB1 gene of the participants in two groups. Gene frequencies (GF) of HLA-DRB1 and HLA-DQB1 were compared between the two groups and genotype-related relative risk (RR) of HFRS was calculated. Pearson linear correlation analysis was adopted to explore correlation between HLA-DRB1 and DQB1 gene polymorphism and HFRS.
      Results  Totally 12 and 13 allele locus of HLA-DRB1 gene were detected in the HFRS patients and the controls. The GF of HLA-DRB1*16 allele of the HFRS patients was significantly higher than that of the control group (8.0 % vs. 1.0 %, RR = 6.60, χ2 = 4.39; P < 0.05); no significant between-group differences were observed in the GF of other HLA-DRB1 allele and in the GF of DQB1 allele (P > 0.05 for all). Pearson linear correlation analyses revealed that HLA-DRB1*16 gene was positively correlated with HFRS (odds ratio OR = 2.014, 95 % confidence interval 95 % CI: 0.373 – 10.132; P < 0.05) and HLA-DRB1*10 gene was also positively correlated with HFRS (OR = 2.273, 95 % CI: 0.254 – 9.252; P < 0.05).
      Conclusion  HLA-DRB1*16 and HLA-DRB1*10 gene are positively correlated with HFRS and may be susceptibility gene loci for HFRS.

     

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