Objective  To analyze occurrence features of adverse events following immunization (AEFI) of poliomyelitis vaccines in Hubei province from 2015 to 2017, and to evaluate the safety of the vaccines.

  Methods  We collected reported AEFI cases related to vaccinations of trivalent oral poliomyelitis attenuated live vaccine (tOPV), inactivated poliomyelitis vaccine made from Salk strains (IPV-Salk), inactivated poliomyelitis vaccine made from sabin strains (IPV-Sabin), and bivalent oral poliomyelitis attenuated live vaccine (bOPV) in Hubei province from 2015 to 2017 via AEFI information management system; then we analyzed the data with descriptive epidemiology method.

  Results  During the 3-year period, the incidence rates of AEFI related to vaccinations of tOPV, bOPV, IPV-Salk, and IPV-Sabin ranged between 4.78 per 100 000 doses to 26.94 per 100 000 doses. Of all the AEFI reported, 80% were common reactions and 11.6% – 20.56% were rare reactions. Most of the reported AEFI cases were the small children less than one years old and the male cases was more than the female cases. More than 90% of the reported cases occurred within one day after the vaccination. For the AEFI cases related to the vaccinations of bOPV and tOPV, the incidence rate of first dose was higher than that of follow-up dose, but there was no obvious difference in the incidence rate for the vaccinations of IPV-Salk and IPV-Sabin. The AEFI incidence rate related to the newly listed bOPV and IPV-Sabin was higher than that related to OPV and IPV-Salk but main reactions of the newly listed vaccines were common vaccine reactions and allergic rash.

  Conclusion  The vaccination of poliomyelitis vaccines is highly safe but the surveillance on rare reactions of the vaccination remains to be done.