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杨莉莉, 张永华, 毛洪京, 徐悠. 慢性失眠患者催眠药物使用状况及其影响因素分析[J]. 中国公共卫生, 2019, 35(3): 356-359. DOI: 10.11847/zgggws1119869
引用本文: 杨莉莉, 张永华, 毛洪京, 徐悠. 慢性失眠患者催眠药物使用状况及其影响因素分析[J]. 中国公共卫生, 2019, 35(3): 356-359. DOI: 10.11847/zgggws1119869
Li-li YANG, Yong-hua ZHANG, Hong-jing MAO, . Hypnotic drug use and its influencing factors among patients with chronic insomnia[J]. Chinese Journal of Public Health, 2019, 35(3): 356-359. DOI: 10.11847/zgggws1119869
Citation: Li-li YANG, Yong-hua ZHANG, Hong-jing MAO, . Hypnotic drug use and its influencing factors among patients with chronic insomnia[J]. Chinese Journal of Public Health, 2019, 35(3): 356-359. DOI: 10.11847/zgggws1119869

慢性失眠患者催眠药物使用状况及其影响因素分析

Hypnotic drug use and its influencing factors among patients with chronic insomnia

  • 摘要:
      目的  了解慢性失眠患者催眠药物使用状况及其影响因素,为失眠障碍的规范诊疗提供参考。
      方法  随机抽取2016年1月 — 2017年5月在杭州市睡眠障碍诊疗中心就诊的慢性失眠患者2 371例,完成一般资料和匹兹堡睡眠质量指数问卷(PSQI)、广泛焦虑量表(GAD-7)评估。应用多因素非条件logistic回归模型分析慢性失眠患者催眠药物使用状况的影响因素。
      结果  调查的2 371例患者中,女性1 512例(63.77 %),男性859例(36.23 %),女性平均年龄(40.17 ± 11.78)岁,男性平均年龄(38.76 ± 11.55)岁;使用催眠药物患者1 082例(45.63 %),主要为苯二氮卓类(42.05 %)、非苯二氮卓类药物(21.35 %)和具有催眠作用的抗抑郁药物(19.22 %);不同性别、年龄、受教育程度、病程、失眠严重程度的慢性失眠患者催眠药物使用状况差异有统计学意义(P < 0.05),女性比男性更易使用催眠药物(P < 0.05),年龄越大、受教育程度越低、失眠病程越长、失眠程度越重的患者催眠药物使用可能性越大(P < 0.05);多因素分析显示,年龄、病程和失眠程度是慢性失眠患者使用催眠药物的主要影响因素(P > 0.05)。
      结论  女性、年龄越大、受教育程度偏低、失眠的病程越长、失眠程度越重的慢性失眠患者,催眠药物使用的频率往往越高。

     

    Abstract:
      Objective  To understand the use of hypnotic drugs and its influencing factors in patients with chronic insomnia and to provide references for the standard diagnosis and treatment of insomnia.
      Methods  Based on preliminary assessment with The Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5), we randomly selected 2 371 chronic insomnia patients seeking medical service at 5 sleep disorder clinics of Hangzhou City Sleep Disorder Diagnosis and Treatment Center from January 2016 to May 2017; then we conducted an internet-based self-administered questionnaire survey using Pittsburgh Sleep Quality Index (PSQI) and the Generalized Anxiety Disorder 7-Item (GAD-7) among the patients. Unconditional multivariate logistic regression model was used to analyze influencing factors of hypnotic drug use.
      Results  Of all the patients, 1 512 (63.77%) and 859 (36.23%) were female and male, with the average age of 40.17 ± 11.78 and 38.76 ± 11.55 years, respectively. About a half of the patients (45.63%) reported hypnotic drug use, of them, 42.05%, 21.35%, and 19.22% reporting medication with benzodiazepines, non-benzodiazepines, and hypnotic antidepressants. The reported hypnotic drug use differed significantly by gender, age, education, duration of the disease, and severity of insomnia (P < 0.05 for all). More female patients reported hypnotic drug use than the male patients (P < 0.05) and the patients at elder age, with lower education, with longer duration or higher severity of insomnia reported higher ratios of hypnotic drug use (P < 0.05 for all). Multivariate analysis demonstrated that age, duration of disease and severity of insomnia were main influencing factors of hypnotic drug use among the patients (all P > 0.05).
      Conclusion  The prevalence of hypnotic drug use is higher among the chronic insomnia patients of female gender, at elder age, with lower education, having longer duration and higher severity of insomnia.

     

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