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贲泽, 马亚萍, 陈春梅, 王永, 聂双, 杭胤, 杭飚, 芮芳, 姚敏, 徐庄剑. 0～6岁儿童尿促性腺激素、性激素变化趋势及特点[J]. 中国公共卫生, 2020, 36(7): 1068-1074. DOI: 10.11847/zgggws1120296
引用本文: 贲泽, 马亚萍, 陈春梅, 王永, 聂双, 杭胤, 杭飚, 芮芳, 姚敏, 徐庄剑. 0～6岁儿童尿促性腺激素、性激素变化趋势及特点[J]. 中国公共卫生, 2020, 36(7): 1068-1074. DOI: 10.11847/zgggws1120296
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Ze BEN, Ya-ping MA, Chun-mei CHEN, . Trajectories and characteristics of urinary gonadotropin and sex hormones in healthy 0 – 6 years old children[J]. Chinese Journal of Public Health, 2020, 36(7): 1068-1074. DOI: 10.11847/zgggws1120296
Citation: Ze BEN, Ya-ping MA, Chun-mei CHEN, . Trajectories and characteristics of urinary gonadotropin and sex hormones in healthy 0 – 6 years old children[J]. Chinese Journal of Public Health, 2020, 36(7): 1068-1074. DOI: 10.11847/zgggws1120296
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0～6岁儿童尿促性腺激素、性激素变化趋势及特点

Trajectories and characteristics of urinary gonadotropin and sex hormones in healthy 0 – 6 years old children

    摘要
  • 摘要:
      目的  研究0～6岁正常儿童尿促性腺激素和性激素变化趋势和特点，旨在为儿童小青春期、性早熟等流行病学调研和临床应用提供前期研究资料。
      方法  于2016年5月 — 2017年10月，留取江苏省无锡市马山和胡埭社区0～6岁920名正常儿童过夜清晨尿，采用免疫化学发光法检测尿促性腺激素和性激素，并用肌酐（Cr）校正。
      结果  成功留取并检测920名儿童尿液，其中男童471人，女童449人，男、女童经肌酐校正的尿黄体生成素（ULH/Cr）M（P25～P75）分别为29.36（17.72～65.05）和33.31（20.47～76.46）U/mol，差异无统计学意义；经肌酐校正的尿卵泡刺激素（UFSH/Cr）分别为473.37（304.15～758.17）和2 414.57（1 444.80～4 212.84）U/mol，男童低于女童，差异有统计学意义（t = – 16.61，P = 0.000）；经肌酐校正的尿雌三醇（UE3/Cr）分别为21.58（16.06～32.47）和24.18（18.57～35.53）μg/mol，男童低于女童，差异有统计学意义（t = – 0.857，P = 0.001）；经肌酐校正的尿雌二醇（UE2/Cr）分别为34.89（24.08～59.87）和32.08（22.33～54.39）μg/mol，差异无统计学意义。男女童尿促性腺激素及性激素均随年龄增加而呈下降趋势。在男童，UE2/Cr自1.5岁～组下降趋缓，其余激素均自6月～组下降趋缓；在女童，ULH/Cr、UE2/Cr自2岁～组、UFSH/Cr自5岁～组、UE3/Cr自6月龄～组、UPro/Cr自3岁～组下降趋缓。
      结论  0～6岁正常儿童尿促性腺激素及性激素均随年龄增加呈下降趋势，且具有性别和激素特点。

     

    Abstract:
      Objective  To observe changing trends and characteristics of urinary gonadotropin and sex hormones in healthy children aged 0 – 6 years and to provide preliminary references for researches on mini-puberty and precocious puberty.
      Methods  First morning urinary samples were collected from 920 healthy 0 – 6 years old children (471 boys and 449 girls) in two communities of Wuxi city, Jiangsu province between May 2016 and October 2017; urinary gonadotropin and sex hormones were determined using immunochemiluminometric assay with creatinine (Cr) correction.
      Results  The median (25% percentile P25 – 75% percentile P75) of urinary luteinizing hormone corrected by creatinine (ULH/Cr) was 29.36 (17.72 – 65.05) U/mol and 33.31 (20.47 – 76.46) U/mol in the boys and girls, without significant gender difference. The median (P25 – P75) of urinary follicle stimulating hormone corrected by creatinine (UFSH/Cr) among the boys was 473.37 (304.15 – 758.17) U/mol and was significantly lower than that (2 414.57 1 444.80 – 4 212.84 U/mol) among the girls (t = – 16.61, P < 0.001). The median (P25 – P75) of urinary estriol corrected by creatinine (UE3/Cr) among the boys was 21.58 (16.06 – 32.47) μg/mol and was significantly lower than that (24.18 18.57 – 35.53 μg/mol) among the girls (t =– 0.857, P = 0.001). The median (P25 – P75) of urinary estradiol corrected by creatinine (UE2/Cr) was 34.89 (24.08 –59.87) μg/mol and 32.08 (22.33 – 54.39) μg/mol among the boys and girls, without significant gender difference. The urinary gonadotropin and sex hormone presented a decreasing trend with the increment of age in both the boys and the girls. The decrease in UE2/Cr slows down at the age of 1.5 years and the decreases in other sex hormones slows down at the age of 6 months among the boys; while, among the girls the decreases in ULH/Cr and UE2/Cr slow down at the age of 2 years and the decreases in UFSH/Cr, UE3/C, and urinary progesterone corrected by creatinine (UPro/Cr) slow down at the age of 5 years, 6 months, and 3 years, respectively.
      Conclusion  Urinary gonadotropin and sex hormone decrease with the increment of age and the decreases differ by gender and various hormones among 0 – 6 years old healthy children.

     

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