PM2.5对慢性阻塞性肺疾病发生发展影响及药物治疗研究进展
Progress in researches on effect of PM2.5 on occurrence and development of chronic obstructive pulmonary disease and medication of the disease
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摘要: 慢性阻塞性肺疾病（慢阻肺）是一种以气流受限为特征可以预防和治疗的疾病，与肺部对有害气体的异常炎症及免疫反应有关。目前环境问题受到广泛关注，细颗粒物（PM2.5）作为危害严重的环境污染物，其对健康的影响不容忽视。研究表明PM2.5在慢阻肺发生发展的过程中起到重要作用。PM2.5主要通过氧化应激、炎症反应和免疫功能失衡影响慢阻肺的进展。本文从慢阻肺危险因素入手，综述PM2.5对慢阻肺疾病发生发展影响的可能机制，分析不同药物对PM2.5影响下慢阻肺进展的干预, 为慢阻肺的预防与治疗提供新的思路。Abstract: Chronic obstructive pulmonary disease, characterized by chronic airflow limitation and being preventable and curable, is usually associated with some abnormal inflammatory response induced by hazardous gases. Recent studies have demonstrated that particulate matter less than 2.5 μm in aerodynamic diameter (PM2.5) may exert a regulatory effect on chronic obstructive pulmonary disease. The study summarized the occurrence and development of the chronic obstructive pulmonary disease and analyzed the progress in medication of the disease for the prevention and control of the disease.
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