Objective  To analyze the influence of maternal anti-poliovirus antibodies on the immune response of different dose Sabin inactivated poliovirus vaccine (sIPV) among infants.

  Methods  We recruited 360 two-month (60 – 90 days) old infants in Pizhou city of Jiangsu province during 2016 – 2017 and vaccinated the infants with three doses of sIPV. Two milliliters venous blood were sampled from each of the infants one month before and after the vaccination for the detection of type I, II and III neutralizing antibodies to poliovirus with neutralization test. The effectiveness and influence factors of the immune response of sIPV were evaluated.

  Results  For the 342 infants with valid information, the mean seropositive rate of type I, II and III antibody were all equal to or above 99.13% among the infants with low/moderate/high dose sIPV vaccination. For the infants with the low/moderate/high dose sIPV vaccination and with the antibody titer of less than 1 : 8 before the vaccination, the geometric mean increases (GMIs) were 1 289.14/1 312.49/2 430.83 for type I, 51.86/101.35/141.04 for type II, and 338.25/540.45/760.52 for type III antibody; the GMIs were 209.54/458.39/454.71 for type I, 7.89/18.10/34.81 for type II, and 116.88/260.05/192.83 for type III antibody among the infants receiving low/moderate/high dose sIPV vaccination and with the antibody titer of equal to or greater than 1 : 8 but less than 1 : 32 before the vaccination; while, the GMIs were 25.35/34.16/90.48 for type I, 1.05/6.17/4.26 for type II, and 11.39/20.97/42.22 for type III antibody among the infants receiving low/moderate/high dose sIPV vaccination and with the antibody titer of greater than 1 : 32 before the vaccination, respectively.

  Conclusion  The immunogenicity of sIPV is generally good and maternal anti-poliovirus antibodies could alleviate the immunogenicity of sIPV at some extent among two-month old infants.