Objective  To examine the utilization of mother-to-child transmission prevention service and its influencing factors among migrant pregnant women with syphilis infection in Zhejiang province and to provide a reference for optimizing the strategies on prevention of mother-to-child transmission (PMTCT) of syphilis.

  Methods  We extracted the data on 3 738 migrant pregnant women with syphilis infection registered in Zhejiang province between January 1, 2013 to December 31, 2017 from national direct network report system for PMTCT of AIDS, syphilis and hepatitis B. The status and associated factors of anti-syphilis treatment and standardized therapy among the pregnant women were analyzed.

  Results  Among all the pregnant women, 3 081 (82.4%) had anti-syphilis treatment and of the women with the treatment, 2 083 (66.1%) received standardized therapy. Multivariate logistic regression analysis revealed that the pregnant women being ethnic minorities, unmarried, having early pregnancy detection, with co-infection of human immunodeficiency virus (HIV) or hepatitis B virus (HBV), and having one or more parities were less likely to have anti-syphilis treatment; for the women with anti-syphilis treatment, those aged 30 years and above were more likely to have standardized therapy, while those unmarried or having one or more parities were less likely to have standardized therapy.

  Conclusion  The anti-syphilis treatment, especially standardized therapy, needs to be improved and both the anti-syphilis treatment and standardized therapy are mainly influenced by marital status and the parity number among the migrant pregnant women with syphilis in Zhejiang province.