高级检索

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

广东省汉族人群RXRA基因rs11185660位点单核苷酸多态性与2型糖尿病遗传易感性关系

王姝 徐霖 胡维 杨辉煌 闫妍 王星杰 潘海燕 孔丹莉 丁元林 于海兵

王姝, 徐霖, 胡维, 杨辉煌, 闫妍, 王星杰, 潘海燕, 孔丹莉, 丁元林, 于海兵. 广东省汉族人群RXRA基因rs11185660位点单核苷酸多态性与2型糖尿病遗传易感性关系[J]. 中国公共卫生, 2020, 36(12): 1785-1788. doi: 10.11847/zgggws1123857
引用本文: 王姝, 徐霖, 胡维, 杨辉煌, 闫妍, 王星杰, 潘海燕, 孔丹莉, 丁元林, 于海兵. 广东省汉族人群RXRA基因rs11185660位点单核苷酸多态性与2型糖尿病遗传易感性关系[J]. 中国公共卫生, 2020, 36(12): 1785-1788. doi: 10.11847/zgggws1123857
WANG Shu, XU Lin, HU Wei, . Association between single nucleotide polymorphism of RXRArs11185660 and genetic susceptibility of type 2 diabetes mellitus in Guangdong Han population[J]. Chinese Journal of Public Health, 2020, 36(12): 1785-1788. doi: 10.11847/zgggws1123857
Citation: WANG Shu, XU Lin, HU Wei, . Association between single nucleotide polymorphism of RXRArs11185660 and genetic susceptibility of type 2 diabetes mellitus in Guangdong Han population[J]. Chinese Journal of Public Health, 2020, 36(12): 1785-1788. doi: 10.11847/zgggws1123857

广东省汉族人群RXRA基因rs11185660位点单核苷酸多态性与2型糖尿病遗传易感性关系

doi: 10.11847/zgggws1123857
基金项目: 2018年度广东省医学科研基金项目(B2018074);2018年度省科技发展专项资金(基础与应用基础研究方向)博士科研启动(2018A030310115);2018年东莞市社会科技发展(一般)项目(20185071521339);2017年广东高校省级重点平台和重大科研特色创新类项目(2017KTSCX084);广东医科大学2017年度博士学位人员和人才引进人员科研启动项目(自然科学类)(B2017010);2018年广东省大学生创新创业训练计划项目(201810571102);广东省自然科学基金项目(2016A030313674);2018广东医科大学大学生创新创业训练计划项目(GDMU2018098;GDMU2018109)
详细信息
    作者简介:

    王姝(1993 – ),女,河南周口人,硕士在读,研究方向:慢性病流行病学

    通信作者:

    于海兵,E-mail:hby616688@163.com

  • 中图分类号: R 181.3+3

Association between single nucleotide polymorphism of RXRArs11185660 and genetic susceptibility of type 2 diabetes mellitus in Guangdong Han population

  • 摘要:   目的  了解广东省汉族人群RXRA基因rs11185660位点的单核苷酸多态性(SNP)与2型糖尿病(T2DM)遗传易感性的关系,为中国汉族人群T2DM发病的分子机制提供科学依据。  方法  采用病例对照研究方法,对2011年11月 — 2013年10月在广东省10家医院内分泌科招募的1 092例20~70岁T2DM患者和同期在医院体检且按地区和年龄匹配的1 092名20~70岁健康人群进行问卷调查、体格检查和RXRA rs11185660位点基因型检测。  结果  病例组T2DM患者和对照组健康人群中RXRA rs11185660位点T、C等位基因频率分别为83.2 %、16.8 %和83.3 %、16.7 %,TT、TC、CC基因型频率分别为69.0 %、28.4 %、2.6 %和68.8 %、29.1 %、2.1 %,2组等位基因频率和基因型频率分布差异均无统计学意义(均P > 0.05);在调整年龄、体质指数、性别前后,病例组和对照组RXRA基因rs11185660位点共显性、显性、隐性和超显性遗传模型间差异均无统计学意义(均P > 0.05)。  结论  广东省汉族人群RXRA基因 rs11185660位点SNP与T2DM患者遗传易感性不存在明显相关性。
  • 表  1  不同组别人群等位基因和基因型频率分布情况比较

    组别 病例组 对照组 χ2 P
    例数 % 人数 %
    等位基因 T 1 775 83.2 1757 83.3 0.012 0.913
    C 359 16.8 351 16.7
    基因型 TT 736 69.0 725 68.8 0.749 0.687
    TC 303 28.4 307 29.1
    CC 28 2.6 22 2.1
    下载: 导出CSV

    表  2  不同组别人群遗传模型比较

    模型 病例组 对照组 OR 95 % CI ORa 95 % CI a
    例数 % 人数 %
    共显性 T/T 736 68.98 725 68.78 1.00 1.00
    T/C 303 28.40 307 29.13 0.97 0.80~1.17 1.00 0.82~1.21
    C/C 28 2.62 22 2.09 1.25 0.71~2.21 1.35 0.76~2.41
    显性 T/T 736 68.98 725 68.79 1.00 1.00
    T/C + C/C 331 31.02 329 31.21 0.99 0.82~1.19 1.02 0.85~1.24
    隐性 T/T + T/C 1 039 97.38 1 032 97.91 1.00 1.00
    C/C 28 2.62 22 2.09 1.26 0.72~2.22 1.35 0.77~2.40
    超显性 T/T + C/C 764 71.60 747 70.87 1.00 1.00
    T/C 303 28.40 307 29.13 0.97 0.80~1.17 0.99 0.82~1.20
    下载: 导出CSV
  • [1] 栗新燕, 邹晨辰, 周思宁, 等. 大连市社区居民2型糖尿病发病影响因素病例对照研究[J]. 中国公共卫生, 2016, 32(11): 1459 – 1462. doi: 10.11847/zgggws2016-32-11-03
    [2] Ishaque A, Shahzad F, Muhammad FH, et al. Diabetes risk assess-ment among squatter settlements in Pakistan: a cross-sectional study[J]. Malaysian Family Physician, 2016, 11(2 – 3): 9 – 15.
    [3] Ebrahimi M, Heidari-Bakavoli AR, Shoeibi S, et al. Association of serum hs-CRP levels with the presence of obesity, diabetes mellitus, and other cardiovascular risk factors[J]. Journal of Clinical Labora- tory Analysis, 2016, 30(5): 672 – 676. doi: 10.1002/jcla.21920
    [4] Cho NH, Shaw JE, Karuranga S, et al. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045[J]. Diabetes Research and Clinical Practice, 2018, 138: 271 – 281. doi: 10.1016/j.diabres.2018.02.023
    [5] Kaur R, Kaur M, Singh J. Endothelial dysfunction and platelet hyperactivity in type 2 diabetes mellitus: molecular insights and therapeutic strategies[J]. Cardiovascular Diabetology, 2018, 17(1): 121. doi: 10.1186/s12933-018-0763-3
    [6] Liu T, Yang W, Pang S, et al. Functional genetic variants within the SIRT2 gene promoter in type 2 diabetes mellitus[J]. Diabetes Research and Clinical Practice, 2018, 137: 200 – 207. doi: 10.1016/j.diabres.2018.01.012
    [7] Cornelis MC, Zaitlen N, Hu FB, et al. Genetic and environmental components of family history in type 2 diabetes[J]. Human Genetics, 2015, 134(2): 259 – 267. doi: 10.1007/s00439-014-1519-0
    [8] Anuradha CV. Phytochemicals targeting genes relevant for type 2 diabetes[J]. Canadian Journal of Physiology and pharmacology, 2013, 91(6): 397 – 411. doi: 10.1139/cjpp-2012-0350
    [9] Moon HU, Ha KH, Han SJ, et al. The association of adiponectin and visceral fat with insulin resistance and beta-cell dysfunction[J]. Journal of Korean Medical Science, 2019, 34(1): e7. doi: 10.3346/jkms.2019.34.e7
    [10] Neuparth MJ, Proenca JB, Santos-Silva A, et al. Adipokines, oxidized low-density lipoprotein, and C-reactive protein levels in lean, overweight, and obese Portuguese patients with type 2 diabetes[J]. ISRN Obesity, 2013, 2013: 142097.
    [11] Riondino S, Roselli M, Palmirotta R, et al. Obesity and colorectal cancer: role of adipokines in tumor initiation and progression[J]. World Journal of Gastroenterology, 2014, 20(18): 5177 – 5190. doi: 10.3748/wjg.v20.i18.5177
    [12] Kyoto Encyclopedia of Genes and Genomes. Adipocytokine signal-ing pathway [EB/OL].[2019 – 07 – 31]. https://www.kegg.jp/kegg-bin/highlight_pathway?scale=1.0&=map04920&keyword=adiponectin%20signaling%20pathWay.
    [13] 陆莹, 杜文聪, 李倩, 等. 应用BP人工神经网络探讨PPAR-γ和RXR-α基因多态性与汉族人群2型糖尿病遗传易感性的关系[J]. 南京医科大学学报: 自然科学版, 2011(1): 1 – 7.
    [14] Chen G, Hu M, Wang XC, et al. Effects of RXRalpha on proli-feration and apoptosis of pancreatic cancer cells through TGF-beta/Smad signaling pathway[J]. European Review for Medical and Pharmacological Sciences, 2019, 23(11): 4723 – 4729.
    [15] Lemkul JA, Lewis SN, Bassaganya-Riera J, et al. Phosphorylation of PPARgamma affects the collective motions of the PPARgamma-RXRalpha-DNA complex[J]. PLoS One, 2015, 10(5): e0123984. doi: 10.1371/journal.pone.0123984
    [16] Lu Y, Ye X, Cao Y, et al. Genetic variants in peroxisome proliferator-activated receptor-γ and retinoid X receptor-α gene and type 2 diabetes risk: a case-control study of a Chinese Han population[J]. Diabetes Technology and Therapeutics, 2011, 13(2): 157 – 164. doi: 10.1089/dia.2010.0122
    [17] Wan YJ, Han G, Cai Y, et al. Hepatocyte retinoid X receptor-alpha-deficient mice have reduced food intake, increased body weight, and improved glucose tolerance[J]. Endocrinology, 2003, 144(2): 605 – 611. doi: 10.1210/en.2002-221003
    [18] Curtis EM, Krstic N, Cook E, et al. Gestational vitamin D supple-mentation leads to reduced perinatal RXRA DNA methylation: results from the MAVIDOS Trial[J]. Journal of Bone and Mineral Research, 2019, 34(2): 231 – 240. doi: 10.1002/jbmr.3603
    [19] 夏诗幻, 于微, 江松, 等. 维生素D改善2型糖尿病相关机制研究进展[J]. 中国公共卫生, 2016, 32(9): 1267 – 1270. doi: 10.11847/zgggws2016-32-09-36
    [20] Heidari B, Nargesi AA, Hafezinejad N, et al. Assessment of serum 25-hydroxy vitamin D improves coronary heart disease risk strati-fication in patients with type 2 diabetes[J]. American Heart Journal, 2015, 170(3): 573 – 579. doi: 10.1016/j.ahj.2015.06.017
    [21] Leung PS. The potential protective action of vitamin D in hepatic insulin resistance and pancreatic islet dysfunction in type 2 diabetes mellitus[J]. Nutrients, 2016, 8(3): 147. doi: 10.3390/nu8030147
    [22] Shi A, Wen J, Liu G, et al. Genetic variants in vitamin D signaling pathways and risk of gestational diabetes mellitus[J]. Oncotarget, 2016, 7(42): 67788 – 67795.
    [23] Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation[J]. Diabetic Medicine, 1998, 15(7): 539 – 553. doi: 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
    [24] Ha KH, Kim DJ. Current status of managing diabetes mellitus in Korea[J]. The Korean Journal of Internal Medicine, 2016, 31(5): 845 – 850. doi: 10.3904/kjim.2016.253
    [25] World Health Organization. Global report on diabetes[R]. Geneva: World Health Organization, 2016.
    [26] Wu Y, Ding Y, Tanaka Y, et al. Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention[J]. International Journal of Medical Sciences, 2014, 11(11): 1185 – 1200. doi: 10.7150/ijms.10001
    [27] Liu AY, Silvestre MP, Poppitt SD. Prevention of type 2 diabetes through lifestyle modification: is there a role for higher-protein diets?[J]. Advances in Nutrition (Bethesda, Md), 2015, 6(6): 665 – 673. doi: 10.3945/an.115.008821
    [28] Chatterjee S, Khunti K, Davies MJ. Type 2 diabetes[J]. Lancet (London, England), 2017, 389(10085): 2239 – 2251. doi: 10.1016/S0140-6736(17)30058-2
    [29] Sanghera DK, Blackett PR. Type 2 diabetes genetics: beyond GWAS[J]. Journal of Diabetes and Metabolism, 2012, DOI: 10.4172/2155 – 6156.1000198.
    [30] Sethi I, Bhat GR, Singh V, et al. Role of telomeres and associated maintenance genes in type 2 diabetes mellitus: a review[J]. Diabetes Research and Clinical Practice, 2016, 122: 92 – 100. doi: 10.1016/j.diabres.2016.10.015
    [31] López Rodríguez M, Kaminska D, Lappalainen K, et al. Identi-fication and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells[J]. Genome Medicine, 2017, 9(1): 63. doi: 10.1186/s13073-017-0453-x
    [32] Wang Z, Coleman DJ, Bajaj G, et al. RXRα ablation in epidermal keratinocytes enhances UVR-induced DNA damage, apoptosis, and proliferation of keratinocytes and melanocytes[J]. Journal of Investi-gative Dermatology, 2011, 131(1): 177 – 187. doi: 10.1038/jid.2010.290
    [33] 高振兴. 绿茶提取物EGCG抗乙型肝炎病毒的分子机理研究[D].郑州: 河南农业大学, 2011.
    [34] Goldbergova MP, Spinarova L, Spinar J, et al. RXRA introne poly-morphism and ABO blood groups in chronic heart failure[J]. Central European Journal of Biology, 2010, 5(6): 749 – 756.
    [35] Zhang H, Xu X, Chen L, et al. Molecular determinants of magnolol targeting both RXRα and PPARγ[J]. PLoS One, 2011, 6(11): e28253. doi: 10.1371/journal.pone.0028253
  • 加载中
表(2)
计量
  • 文章访问数:  5306
  • HTML全文浏览量:  3673
  • PDF下载量:  59
  • 被引次数: 0
出版历程
  • 接收日期:  2019-04-14
  • 网络出版日期:  2019-09-06
  • 刊出日期:  2020-12-10

目录

    /

    返回文章
    返回