Abstract:
Objective To investigate the relationship between single nucleotide polymorphism (SNP) of RXRA rs11185660 and genetic susceptibility of type 2 diabetes mellitus (T2DM) in Guangdong Han population and to provide evidences for exploring pathogenesis of T2DM in Chinese Han population.
Methods A case-control study involving questionnaire survey, physical examination and SNP detection of RXRA rs11185660 was conducted among 1 092 T2DM patients aged 20 – 70 years recruited in endocrinology departments of 10 hospitals in Guangdong province between November 2011 and October 2013 and 1 092 age- and living region-matched healthy people having physical examination in hospitals during the same period.
Results In the cases, the T and C allele frequencies of RXRA rs11185660 were 83.2% and 16.8%, similar to those in the controls (83.3% and 16.7%). The frequencies of TT, TC, and CC genotypes were 69.0%, 28.4%, and 2.6% in the cases and 68.8%, 29.1%, and 2.1% in the controls, respectively. There were no significant differences in allele frequencies and genotype frequencies of of RXRA rs11185660 between the cases and the controls (P > 0.05 for all). Before and after adjusting for age, body mass index and gender, there were no significant differences in the codominant, dominant, recessive, and superdominant genetic models of RXRA rs11185660 between the cases and the controls (all P > 0.05).
Conclusion The study results suggest that there is no significant correlation between single nucleotide polymorphism of RXRA rs11185660 and genetic susceptibility of type 2 diabetic mellitus in Guangdong Han population.
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