农药与多环芳烃联合暴露致神经发育毒性

张伟; 王炳玲; 高汝钦

doi:10.11847/zgggws1123903

农药与多环芳烃联合暴露致神经发育毒性

Developmental neurotoxicity of combined exposure to pesticides and polycyclic aromatic hydrocarbons: a literature study

摘要

摘要:
目的从基因水平探讨儿童早期多环芳烃（PAHs）暴露过程中，联合暴露农药在PAHs神经发育毒性中可能联合作用的生物学机制。
方法通过毒理学数据网络（TOXNET）获取已知农药1 337种，并在比较毒理基因组学数据库（CTD）中获取这些农药与16种常见PAHs作用的有确切证据的神经发育性障碍相关基因。对农药与PAHs共同基因进行基因富集分析，获取共同基因/蛋白可能参与的生物进程或信号通路。
结果共计562个神经发育障碍关联基因与PAHs和农药同时存在相互作用。238个关键基因/蛋白富集发现，这些基因参与了化学突触传递及其调节、大脑发育等生物进程和5 – 羟色胺能神经突触、神经活性配体 – 受体相互作用信号通路。
结论农药和PAHs能够在基因水平上联合作用产生神经发育毒性。

Abstract:
Objective To preliminarily explore developmental neurotoxicity and possible biological mechanism of combined exposure to pesticides and polycyclic aromatic hydrocarbons (PAHs) during early childhood using comparative genomics method.
Methods Relevant data on 1 337 commonly used pesticides were extracted from Toxicology Data Network. Information on confirmed genes associated with neurodevelopmental toxicity of 16 common PAHs were retrieved from the Comparative Toxicogenomics Database. The genes related to the metabolism of both the pesticides and the PAHs were identified to analyze possible biological processes and pathways correlated with the developmental neurotoxicity of the combined exposure.
Results A total of 562 genes were identified to be associated with neurodevelopmental disorders (NDDs)-related exposures to both PAHs and pesticides, of them, 238 key genes were mainly involved in synaptic transmission and regulation of neurotransmitter, brain development processes, and pathways of serotonin A synapse and neuroactive ligand-receptor interaction.
Conclusion Combined exposure to pesticides and PAHs could cause gene-mediated neurodevelopmental toxicity.

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