Abstract: With the process of global warming and the intensity and frequency of heat wave attacks, the incidence and mortality of heat stroke are increasing year by year, which may become an emergency event of public health. The biomarkers predicting the occurrence and development of heat stroke will help to understand heat radiation diseases more conveniently and effectively, and further develop prevention and control measures. This study reviews the biomarkers used in heat stroke diagnosis in recent years, and discusses the latest progress in their clinical application.