中国20世纪60年代初期出生人群肥胖相关基因多态性分布

李卉; 宋超; 马彦宁; 姚业成; 刘爱玲; 胡小琪

doi:10.11847/zgggws1124649

中国20世纪60年代初期出生人群肥胖相关基因多态性分布

Distribution of obesity-associated gene polymorphisms among Chinese population born in early 1960s

摘要

摘要:
目的了解中国1960 — 1961年及1963年出生人群肥胖相关基因多态性分布，为预防肥胖提供依据。
方法从2010 — 2012年中国居民营养与健康状况监测中选取1960 — 1961年和1963年出生的人群作为研究对象，共1 982人，其中男性770人，女性1 212人。采用飞行时间质谱技术对已知的10个肥胖基因单核苷酸多态性（SNP）位点进行检测。
结果中国1960 — 1961年及1963年出生人群的肥胖基因位点不存在性别差异（P > 0.05）；rs11030104和rs6265的风险等位基因在少数民族中的频率均高于汉族（χ² = 16.185、12.962，P < 0.001）；本调查人群和日本东京人群风险等位基因频率存在差异的位点分别为rs11030104、rs1558902、rs6265、rs9939609（P均 < 0.05）；与美国犹他州的北欧和西欧人后裔比较，存在差异的位点为rs11030104、rs16892496、rs2568958、rs6265、rs7561317、rs7832552、（P均 < 0.01）；和美国西南部非洲人后裔相比，存在差异的位点为rs11030104、rs16892496、rs2568958、rs574367、rs6265、rs7561317、rs7832552、rs9939609（P均 < 0.05）；和美国洛杉矶人群比较，rs11030104、rs1558902、rs2568958、rs574367、rs6265、rs9939609等位点与本研究的携带频率存在差异（P均 < 0.01）。
结论中国20世纪60年代初期出生人群的肥胖相关基因多态性无性别差异；汉族和少数民族有2个位点存在差异；不同种族间的风险等位基因频率存在差异，中国人群多数基因位点的风险等位基因频率高于其他种族人群。

Abstract:
Objective To describe the distribution of obesity-associated gene polymorphisms among Chinese population born in the year of 1960 – 1961 and 1963, and to provide evidences for obesity prevention.
Methods A total of 1 982 people (770 males and 1 212 females) born in the year of 1960 – 1961 and 1963 were selected from the participants of China National Nutrition and Health Surveillance conducted in 2010 – 2012. Single nucleotide polymorphism (SNP) of 10 obesity-associated genes were detected with time-of-flight mass spectrometry.
Results No significant gender differences were observed in the SNP of the 10 genes (P > 0.05 for all). Significantly higher frequency of risk allele of rs11030104 and rs6265 were detected among minority ethnic participants than among Han participants (χ² = 16.185, χ² = 12.962; both P < 0.001). Compared to those in published international studies, significant racial differences were observed in the distributions of SNP of the risk alleles among the participants for following loci: rs11030104, rs1558902, rs6265, and rs9939609 compared to a population in Tokyo of Japan (all P < 0.05); rs11030104, rs16892496, rs2568958, rs6265, rs7561317, and rs7832552 in contrast to the descendants of Western Europeans and Nordics in Utah of the United States (all P < 0.01); rs11030104, rs16892496, rs2568958, rs574367, rs6265, rs7561317, rs7832552, and rs9939609 in comparison to the descendants of Africans in southwest region of the United States (all P < 0.05); and rs11030104、rs1558902, rs2568958, rs574367, rs6265, and rs9939609 compared to a population in Los Angeles of the United States (all P < 0.01).
Conclusion There is no significant gender differences in the SNP of the 10 obesity-associated genes among Chinese populations born in early 1960′s but there is a ethnic difference in the two loci of risk alleles between the minority and Han population. There are racial differences in the risk allele frequency and the frequencies for the majority of the 10 obesity-associated genes are higher among the Chinese population than those among other racial groups in foreign countries.

HTML全文

参考文献(20)

施引文献

资源附件(0)