Abstract: With the prevalence of chronic diseases and the increasing cost of health care, the economic burden and risk caused by chronic diseases have attracted more and more attentions from all walks of life. How to analyze this complex problem is still lack of a systematic and comprehensive analysis framework in China. On the basis of literature research, we discuss the multi-dimensional analysis framework for chronic disease cost burden and risk research through multi-dimensional quantitative research and impact factor analysis, combined with the comprehensive application of qualitative methods such as focus group discussion. A comprehensive analysis framework of burden and economic risk of chronic disease population was constructed considering the perspectives of population structure characteristics, spatial geographical distribution characteristics, socio-economic characteristics, health related behavior characteristics, health and disease status, and health service utilization characteristics. The constructed framework could provide a systemic analysis method for the overall grasp and accurate outline of the distribution characteristics of high economic burden and risk families, target more accurately the population with chronic diseases iducing high economic risk, and provide references for decision makers to develop targeted intervention strategies and measures.