Abstract:
Objective To analyze survival rate and its related factors in human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients with antiretroviral therapy (ART) in Guangxi Zhuang Autonomous Region (Guangxi).
Methods We collected information on 2 174 HIV/AIDS patients registered at health care clinics in Guangxi for their first ART from December 2003 through 2017 for a retrospective cohort study. The cumulative survival rate of patients was calculated with life table method and Cox proportional hazards model was used to analyze influencing factors of the patients′ survival.
Results The median age of the patients was 35.35 ± 12.38 years and the median duration of follow-up was 64.34 ± 47.63 months. The overall mortality was 0.978/100 person-years and the average survival time was 158.27 months (95% confidence interval = 156.46 – 160.08) with a 14-year survival rate of 89.79% by the end of the follow-up. The results of multivariate Cox regression analyses demonstated that age, baseline CD4+T lymphocyte cell count and transmission route were influential factors of the survival rate.
Conclusion The survival rate of patients receiving ART at health care clinics of Guangxi is relatively high, but special attention should be paid to the patients less than 30 years old and with a baseline CD4+T lymphocyte cell count less than 200/μL at the initial treatment, and those infected via homosexual transmission.
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