Abstract: Four laboratory-confirmed novel coronavirus disease (COVID-19) cases were diagnosed in a family in Lingyuan prefecture of Liaoning province within 8 days from January 24, 2020, about 3 weeks after the epidemic outbreak first reported from Wuhan, China, on 31 December 2019. The first case of the clustering – a 42 years old male was diagnosed 5 days after the occurrence of clinical symptoms; four days later, both the first case′s father (72 years) and wife (42 years) were diagnosed with COVID-19 and the first case′s four years old daughter was confirmed as an asymptomatic COVID-19 patients on January 31, 2020. All the four cases had the history of living in Wuhan city two weeks before the incidence of the disease but no histories of contact with someone with fever or cough symptom, shopping in farmer′s market, or contact with wild animals while living in Wuhan city.