Abstract: To provide a reference for economic evaluation on human papillomavirus (HPV) vaccine vaccination, we briefly introduced the application of transmission dynamics model in HPV vaccine vaccination economic evaluation and related calculation methods. In the transmission dynamics model-based evaluation on vaccination of bivalent HPV vaccine, the population is divided into various age groups and individual activity levels; an ordinary differential equation set is established to simulate the transmission of HPV16/18 virus infection in the population and the occurrence of related diseases; and the health output of disease prevention is calculated in combination with the protection efficiency of the vaccine. The transmission dynamics model is a dynamic progress model, which is more realistic than the simulation results of static progress models such as Markov. However, due to the lack of some key parameters and large-scale population survey data in China, the quality of the economic evaluation on HPV vaccine vaccination is affected to some extent. Considering on the absence of some parameters for the evaluation nowadays, some data from other countries could be utilized in transmission dynamics model-based economic evaluation on HPV vaccine vaccination to obtain more accurate analysis results.