Objective  To evaluate the effect and mechanism of intervention measures for the elimination of mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) in Yunnan province from 2006 to 2019 for providing evidences to the control of MTCT of HIV in other regions.

  Methods   Information on implemented strategies and measures for prevention of MTCT of HIV in Yunnan province since 2006 were collected with literature reviews. Case records and follow-up registration cards for HIV-infected puerperae and their newborns and monthly reports for the prevention of MTCT of HIV in Yunnan province from 2006 through 2019 were extracted from National Information Management System for Prevention of MTCT of HIV. The collected data were analyzed statistically and relevant indicators were calculated to evaluate the efficiency of the implemented strategies and measures in the province.

  Results  Relevant management process and system were established in the province to ensure the implementation of HIV antibody testing in all pregnant women and all measures for HIV-infected puerperae and their newborns including anti-viral treatment, health care, follow-up detection, referral, individualized management and infection assessment, and information monitoring. From 2006 to 2019, the detection rate of HIV antibody in pregnant women increased from 79.09% to 99.97% and the HIV antibody detection rate during the pregnancy increased from 44.56% to 99.89%; the rate of anti-viral treatment among HIV-infected puerperae and their children increased from 75.92% to 99.72%, and from 86.90% to 99.91%, respectively; whereas, the adjusted the rate of MTCT of HIV decreased from 8.78% to 1.93%.

  Conclusion   In Yunnan province, the strategies and measures implemented from 2006 to 2019 for elimination of of MTCT of HIV were effective and major outcome indicators for the control of MTCT of HIV met the requirements proposed by World Health Organization.