Abstract: Yunnan province is expected to be a radiate center for Southeast and South Asia in the Belt and Road Initiatives. Since 2005, China has initiated an international joint project for the control of malaria and dengue fever in Yunnan province in response to the challenge of tropical disease epidemic in the region. Fifteen years after the initiation of the project, collaborative consensus and framework have been constructed among project partners, with the establishments of 5 liaison offices, 21 cross-border monitoring sites and 20 joint workstations. The joint prevention and control mechanism was preliminarily established through a variety of measures including coordination meeting, training program, postgraduate education, technical support, campaign in World Malaria Day, joint survey, establishment of monitoring platform and joint laboratory. The joint project has achieved remarkable success and may provide some implications to other China-aid foreign public health projects.