Abstract: Singapore is a mature free trade port recognized by the international community. In the process of port construction, the improvement of public health system has been attached to a great importance and many indicators of sustainable development of public health were ranked at the forefront of the world. Especially during the coronavirus disease 2019 epidemic, the effectiveness of Singapore′s epidemic prevention and control has been widely recognized by countries, and the implemented emergency measures are also known as “epidemic prevention samples” for the international community. In the study, we summarize Singapore′s advanced practices in the process of public health system construction and discuss the practices′ enlightenment on Hainan Free Trade Port′s public health system construction for promoting the development of public health system in Hainan province.