Abstract: As an important part of the International Health Regulations, risk communication plays a significant role in the response and management of public health emergencies. Recommended by World Health Organization (WHO), the five principles for risk communication practice include building trust, releasing information timely, information transparency, paying attention to the public, and formulating preplan. In the study, we analyze and summarize the application of WHO′s five principles of risk communication in the management process of a health emergency response after a strong earthquake occurred in Maduo County, Guoluo Tibetan Autonomous Prefecture, Qinghai Province in May 2021 for providing a reference to prospective practice in future.