Objective  To investigate the acceptability and willingness to recommend human papillomavirus (HPV) vaccine in Chinese women, cervical cancer patients, health workers and governmental officers after coronavirus disease 2019 (COVID-19) epidemic.

  Methods  With stratified cluster random sampling, a face-to-face questionnaire survey was conducted from December 2020 to April 2021 among 3 791 persons with different identities in seven geographical regions of China.

  Results   Among the 3 599 respondents with complete information, the proportion (number) of persons having heard about HPV vaccine was 80.4% (1 387) in general women, 80.0% (296) in cervical cancer patients, 92.8% (989) in health workers, and 95.7% (419) in government officers, respectively, and the proportion was relatively higher in women and the respondents with higher education. In the female respondents with daughters, 341 (82.0%) general women and 176 (67.2%) cervical cancer patients reported the willingness to have their daughters being vaccinated. Of the health workers, 79.3% (784) expressed the willingness to recommend HPV vaccine to attendees in their routine work. Among government officers, 428 (97.7%) demonstrated a positive attitude toward HPV vaccination promotion, of which, 93.2% (399) considered that the women of right ages should be encouraged to receive HPV vaccine voluntarily and 318 (74.3%) thought that HPV vaccine should be included in national vaccination program for large-scale promotion of HPV vaccination.

  Conclusion  After the incidence of COVID-19 epidemic, the willingness of having HPV vaccination increased among Chinese women but parental willingness to have their daughters being vaccinated was low. Despite high willingness of HPV vaccination promotion among governmental officers, the intention of recommending HPV vaccine to attendees in their routine work is not strong among health workers. The results suggest that specific health education on HPV vaccine is important for promoting HPV vaccination willingness in the public.