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中国居民1990 — 2019年皮肤及皮下疾病疾病负担变化趋势

陈东宇 杨晓雨 王红心 樊文龙 刘兴华 林泳煌 何玉清

陈东宇, 杨晓雨, 王红心, 樊文龙, 刘兴华, 林泳煌, 何玉清. 中国居民1990 — 2019年皮肤及皮下疾病疾病负担变化趋势[J]. 中国公共卫生, 2022, 38(5): 529-533. doi: 10.11847/zgggws1137391
引用本文: 陈东宇, 杨晓雨, 王红心, 樊文龙, 刘兴华, 林泳煌, 何玉清. 中国居民1990 — 2019年皮肤及皮下疾病疾病负担变化趋势[J]. 中国公共卫生, 2022, 38(5): 529-533. doi: 10.11847/zgggws1137391
CHEN Dong-yu, YANG Xiao-yu, WANG Hong-xin, . Changing trend in disease burden of skin and subcutaneous diseases among Chinese residents, 1990 – 2019[J]. Chinese Journal of Public Health, 2022, 38(5): 529-533. doi: 10.11847/zgggws1137391
Citation: CHEN Dong-yu, YANG Xiao-yu, WANG Hong-xin, . Changing trend in disease burden of skin and subcutaneous diseases among Chinese residents, 1990 – 2019[J]. Chinese Journal of Public Health, 2022, 38(5): 529-533. doi: 10.11847/zgggws1137391

中国居民1990 — 2019年皮肤及皮下疾病疾病负担变化趋势

doi: 10.11847/zgggws1137391
基金项目: 国家自然科学基金(81773312);广东省自然科学基金(2015A030313517);广东省“扬帆计划引进紧缺拔尖”人才项目(201433005);东莞市社会发展重点项目(20211800905552)
详细信息
    作者简介:

    陈东宇(1996 – ),男,广东湛江人,硕士在读,研究方向:临床流行病

    通信作者:

    何玉清,E-mail:dr.hyq@hotmail.com

  • 中图分类号: R 195.4;R 18

Changing trend in disease burden of skin and subcutaneous diseases among Chinese residents, 1990 – 2019

  • 摘要:   目的  分析中国居民1990 — 2019年皮肤及皮下疾病疾病负担的变化趋势,为我国公共卫生政策的制定提供理论依据。  方法  收集2019年全球疾病负担(GBD 2019)研究中1990、2000、2010和2019年中国居民皮肤及皮下疾病疾病负担相关数据,采用发病数、标化发病率、患病数、标化患病率、伤残调整寿命年(DALY)、标化DALY率和估计年百分比变化(EAPC)等指标分析1990 — 2019年中国居民皮肤及皮下疾病疾病负担的变化趋势。  结果  中国居民1990 — 2019年皮肤及皮下疾病的发病数、标化发病率、患病数、标化患病率和DALY分别增长了29.33 %、27.20 %、27.23 %、5.52 %和14.75 %,但标化DALY率则降低了0.29 %;女性居民标化发病率低于同时期男性居民,但标化患病率和标化DALY率均高于同时期男性居民。中国居民1990 — 2019年皮肤及皮下疾病标化发病率增长最快的为褥疮(EAPC = 1.078,95 % UI = 0.826~1.317),下降最快的为蜂窝织炎(EAPC = – 1.210,95 % UI = – 1.416~– 1.019);标化患病率增长最快的为寻常痤疮(EAPC = 1.087,95 % UI = 1.052~1.110),下降最快的为蜂窝织炎(EAPC = – 1.097,95 % UI = – 1.289~– 0.917);标化DALY率增长最快的为褥疮(EAPC = 2.202,95 % UI = 0.905~3.451),下降最快的是蜂窝织炎(EAPC = – 7.304,95 % UI = – 8.081~– 7.087)。  结论  中国居民1990 — 2019年皮肤及皮下疾病的发病率和患病率有所增加,疾病负担虽有所改善但仍处于较高水平,其中对疾病负担增长最快的褥疮应加以重视。
  • 表  1  中国居民1990 — 2019年皮肤及皮下疾病的疾病负担

    组别年份发病数(万例)标化发病率(1/10万)患病数(万例)标化患病率(1/10万)DALY(万人年)标化DALY率(1/10万)
    例数95 % UI95 % UI例数95 % UI95 % UI人年数95 % UI95 % UI
    男性 1990 31178.21 29685.66~32704.16 53149.19 50810.99~55589.81 14225.73 13786.46~14682.20 23664.94 22996.08~24369.20 345.52 229.51~513.62 572.48 383.73~841.47
    2000 34597.20 32997.70~36319.85 53300.73 50950.91~55726.10 15799.04 1531372.09~16294.49 23997.29 23313.75~24716.34 371.29 244.53~551.76 565.90 373.58~840.33
    2010 36890.39 35138.36~38645.48 53228.15 50846.44~55671.39 16816.85 16301.44~17320.77 24466.64 23773.59~25182.14 380.52 249.34~567.41 561.28 366.47~841.23
    2019 39522.83 37578.64~41306.78 53614.37 51266.65~56003.68 17794.06 17257.37~18312.17 24932.63 24234.48~25646.29 391.04 256.19~581.91 563.28 364.81~848.85
    女性 1990 29472.74 27950.79~30882.95 52787.29 50247.08~55202.64 14786.68 14339.43~15233.39 25796.77 25077.04~26543.28 374.72 245.26~548.02 646.15 426.18~943.77
    2000 32914.28 31292.95~34445.97 52986.31 50483.86~55433.49 16597.84 16129.99~17078.57 26200.64 25476.85~26939.57 409.61 267.43~601.96 648.26 425.03~953.41
    2010 35733.55 34010.83~37374.61 52980.64 50433.34~55382.60 17957.17 17471.07~18472.73 26732.36 25982.82~27507.87 425.12 276.08~625.40 647.53 419.98~959.02
    2019 38916.70 36978.58~40703.09 53427.33 50871.86~55826.88 19118.68 18624.42~19620.08 27257.45 26500.62~28027.25 435.43 281.78~646.05 652.97 422.58~969.57
    合计 1990 60650.96 57638.00~63452.76 52941.09 50579.14~55342.10 29012.41 28157.26~29883.60 24699.41 24027.60~25416.14 720.24 473.29~1061.26 608.09 402.95~895.59
    2000 67511.48 64297.71~70703.74 53120.44 50743.81~55465.37 32396.88 31450.02~33352.68 25074.42 24370.61~25801.33 780.90 510.87~1156.78 606.12 397.39~897.85
    2010 72623.95 69212.79~75931.56 53078.90 50702.81~55425.60 34774.02 33794.45~35752.19 25578.29 24865.99~26314.48 805.64 525.00~1200.65 603.20 392.39~902.24
    2019 78439.53 74601.07~81916.75 53494.13 51104.14~55850.77 36912.74 35906.83~37916.04 26063.10 25348.68~26794.24 826.47 539.48~1235.63 606.34 391.32~909.27
    下载: 导出CSV

    表  2  中国居民1990 — 2019年各类皮肤及皮下疾病的发病情况及标化发病率变化趋势

    疾病1990 年2019 年EAPC95 % UI
    发病数
    (万例)
    95 % UI标化发病率
    (1/10万)
    95 % UI发病数
    (万例)
    95 % UI标化发病率
    (1/10万)
    95 % UI
    特应性皮炎 480.55 459.84~499.81 409.40 393.09~424.47 583.74 557.64~607.75 411.13 394.14~427.17 0.021 0.008~0.035
    接触性皮炎 3997.88 3117.99~5009.33 3572.92 2802.47~4400.01 6382.75 4939.74~7915.65 3574.53 2803.81~4400.46 0.003 0.002~0.003
    脂溢性皮炎 2142.69 1959.45~2320.60 1729.33 1591.34~1862.46 2524.52 2318.74~2732.14 1729.20 1590.59~1862.52 – 0.001 – 0.001~0.001
    银屑病 78.46 75.61~81.30 68.25 65.84~70.70 89.29 85.96~92.43 53.96 52.08~55.79 – 0.798 – 0.816~ – 0.787
    蜂窝织炎 123.61 113.03~133.53 109.05 100.29~117.61 122.13 113.24~131.40 84.00 77.42~90.31 – 1.210 – 1.416~ – 1.019
    脓皮病 7289.03 7052.74~7564.61 6432.49 6227.48~6662.61 9075.17 8816.66~9390.87 6164.80 5987.81~6364.95 – 0.218 – 0.262~ – 0.175
    疥疮 16272.87 14266.24~18512.25 13293.56 11750.64~14923.17 17087.90 15165.09~18923.15 12993.01 11497.41~14585.92 – 0.071 – 0.075~ – 0.068
    真菌性皮肤病 15820.92 14187.66~17610.24 15048.94 13591.68~16668.85 23486.82 21074.62~26238.21 14576.78 13146.78~16228.96 – 0.127 – 0.134~ – 0.120
    病毒性皮肤病 1842.73 1761.11~1925.66 1572.60 1503.02~1644.87 1714.48 1650.94~1779.36 1572.21 1502.72~1644.53 – 0.001 – 0.002~ – 0.001
    寻常痤疮 1993.30 1771.88~2255.91 1555.71 1375.71~1775.96 2019.77 1814.68~2264.07 2086.69 1837.00~2382.25 1.032 1.006~1.049
    斑秃 515.19 494.19~536.04 420.12 404.46~435.61 666.77 641.48~692.07 420.95 405.26~436.50 0.014 0.011~0.018
    瘙痒 855.01 755.11~959.04 772.62 690.58~862.70 1389.90 1220.47~1562.22 844.73 752.85~942.07 0.316 0.304~0.327
    荨麻疹 1585.76 1377.38~1828.43 1310.06 1148.61~1497.03 1693.07 1497.57~1888.73 1305.73 1145.17~1491.75 – 0.010 – 0.011~ – 0.009
    褥疮 10.53 9.19~12.15 15.57 13.62~17.92 31.65 28.13~35.70 19.89 17.64~22.50 1.078 0.826~1.317
    其他皮肤和皮下疾病 7642.43 7430.40~7850.91 6630.47 6461.67~6806.29 11571.56 11281.81~11875.83 7656.52 7461.73~7856.11 0.518 0.500~0.534
    下载: 导出CSV

    表  3  中国居民1990 — 2019年各类皮肤及皮下疾病的患病情况及标化患病率变化趋势

    疾病1990年2019年EAPC95 % UI
    患病数
    (万例)
    95 % UI标化患病率
    (1/10万)
    95 % UI患病数
    (万)
    95 % UI标化患病率
    (万例)
    95 % UI
    特应性皮炎 2831.90 2721.32~2933.90 2434.96 2342.91~2519.90 3558.37 3424.54~3694.20 2460.18 2366.59~2548.51 0.044 0.028~0.059
    接触性皮炎 1457.54 1177.78~1823.50 1302.01 1053.90~1610.32 2311.29 1828.82~2877.94 1302.45 1054.20~1612.59 0.002 0.002~0.003
    脂溢性皮炎 286.37 264.82~308.17 251.69 234.63~268.79 397.12 368.56~426.29 251.69 234.53~268.74 0.001 – 0.001~0.001
    银屑病 633.55 610.31~656.05 577.92 556.62~597.26 765.33 738.58~790.83 434.82 420.27~448.33 – 0.985 – 1.012~ – 0.968
    蜂窝织炎 7.57 6.99~8.16 6.62 6.15~7.12 7.59 7.04~8.17 5.27 4.89~5.67 – 1.097 – 1.289~ – 0.917
    脓皮病 326.39 317.73~335.86 285.39 278.16~293.33 404.39 394.87~415.36 281.51 274.76~288.95 – 0.113 – 0.144~ – 0.082
    疥疮 5375.92 4695.80~6134.53 4387.88 3877.53~4963.09 5672.90 5043.52~6328.60 4288.36 3791.61~4851.79 – 0.072 – 0.075~ – 0.068
    真菌性皮肤病 4870.99 4318.43~5466.46 4600.81 4127.79~5138.03 7064.93 6288.79~7989.85 4425.21 3951.53~4965.78 – 0.155 – 0.164~ – 0.146
    病毒性皮肤病 3276.43 3147.71~3392.30 2742.16 2638.85– 2840.66 3238.44 3125.09~3344.60 2747.47 2643.47~2845.76 0.008 0.006~0.009
    寻常痤疮 4118.50 3695.97~4604.50 3037.89 2732.37~3380.82 4279.35 3910.17~678.42 4124.60 3713.35~4571.75 1.087 1.052~1.110
    斑秃 290.35 278.71~302.44 237.95 228.94~246.97 380.44 366.07~394.63 238.47 229.46~247.57 0.015 0.011~0.018
    瘙痒 1105.35 980.18~1256.82 1002.48 894.53~1127.87 1828.48 1609.62~2090.41 1104.61 984.92~1241.77 0.340 0.328~0.351
    荨麻疹 898.65 777.73~1029.96 741.17 647.56~842.80 963.61 848.32~1077.12 738.71 645.58~839.90 – 0.010 – 0.011~ – 0.009
    褥疮 2.82 2.46~3.25 4.15 3.61~4.75 8.36 7.44~9.41 5.25 4.68~5.94 1.034 0.785~1.273
    其他皮肤和皮下疾病 7454.60 7249.66~7662.94 6464.28 6293.84~6638.44 11357.59 11064.67~11667.73 7461.97 7270.15~7661.12 0.517 0.499~0.533
    下载: 导出CSV

    表  4  中国居民1990 — 2019年各类皮肤及皮下疾病的DALY情况及标化DALY率变化趋势

    疾病1990 年2019 年EAPC95 % UI
    DALY
    (万人年)
    95 % UI标化DALY率
    (1/10万)
    95 % UIDALY
    (万人年)
    95 % UI标化DALY率
    (1/10万)
    95 % UI
    特应性皮炎123.9166.28~207.91105.9656.58~176.97153.9782.42~255.98107.4757.80~178.080.0580.043~0.073
    接触性皮炎36.6223.06~54.6132.4620.43~48.4457.5735.84~86.9532.5820.41~48.730.0140.012~0.016
    脂溢性皮炎3.912.20~6.253.411.93~5.455.363.04~8.573.411.93~5.490.0060.004~0.008
    银屑病55.5939.62~74.2350.2635.93~66.9766.2747.19~87.5837.9326.94~49.94– 0.973– 1.000~ – 0.955
    蜂窝织炎5.612.39~8.655.392.47~7.921.260.97~1.850.850.65~1.23– 7.304– 8.081~ – 7.087
    脓皮病17.9710.08~23.8119.2711.00~24.406.614.97~9.684.313.19~6.51– 6.192– 6.954~ – 5.831
    疥疮139.7175.86~224.57113.6162.55~181.40146.2781.17~233.81111.2761.18~177.85– 0.064– 0.067~ – 0.060
    真菌性皮肤病27.4410.94~59.6425.6310.38~55.8839.2615.82~85.4724.689.94~53.96– 0.152– 0.160~ – 0.143
    病毒性皮肤病101.5864.29~150.8284.8453.83~126.1799.6563.54~147.5685.2254.17~126.590.0170.014~0.020
    寻常痤疮88.7654.06~142.3265.4639.90~105.0492.1855.50~146.2189.0853.68~141.341.0961.060~1.121
    斑秃9.576.01~14.297.824.91~11.6612.487.88~18.537.864.92~11.710.0270.022~0.032
    瘙痒11.815.65~21.1110.635.11~18.9819.359.16~34.7611.745.58~21.070.3480.336~0.359
    荨麻疹54.3335.31~78.5144.6329.27~64.8057.6537.99~81.8644.6429.16~64.950.0030.001~0.005
    褥疮1.130.87~1.802.001.58~3.174.913.94~5.873.162.53~3.752.2020.905~3.451
    其他皮肤和皮下疾病42.3220.43~77.3436.7217.91~66.6463.6831.02~115.0842.1120.57~76.480.4020.339~0.464
    下载: 导出CSV
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  • 接收日期:  2021-11-09
  • 网络出版日期:  2022-04-29
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