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李亚飞, 范威, 王文华, 韩俊锋, 潘静静, 包红红, 王莹莹, 尤爱国, 于铭洋, 王海峰, 叶莹, 黄学勇. 一起由新冠病毒奥密克戎变异株引起的学校聚集性疫情[J]. 中国公共卫生, 2022, 38(5): 614-618. DOI: 10.11847/zgggws1138512
引用本文: 李亚飞, 范威, 王文华, 韩俊锋, 潘静静, 包红红, 王莹莹, 尤爱国, 于铭洋, 王海峰, 叶莹, 黄学勇. 一起由新冠病毒奥密克戎变异株引起的学校聚集性疫情[J]. 中国公共卫生, 2022, 38(5): 614-618. DOI: 10.11847/zgggws1138512
LI Ya-fei, FAN Wei, WANG Wen-hua, Han Jun-feng, Pan Jing-jing, Bao Hong-hong, Wang Ying-ying, You Ai-guo, Yu Ming-yang, Wang Hai-feng, Ye Ying, Huang Xue-yong. A school cluster outbreak of COVID-19 caused by SARS-CoV-2 Omicron variant[J]. Chinese Journal of Public Health, 2022, 38(5): 614-618. DOI: 10.11847/zgggws1138512
Citation: LI Ya-fei, FAN Wei, WANG Wen-hua, Han Jun-feng, Pan Jing-jing, Bao Hong-hong, Wang Ying-ying, You Ai-guo, Yu Ming-yang, Wang Hai-feng, Ye Ying, Huang Xue-yong. A school cluster outbreak of COVID-19 caused by SARS-CoV-2 Omicron variant[J]. Chinese Journal of Public Health, 2022, 38(5): 614-618. DOI: 10.11847/zgggws1138512

一起由新冠病毒奥密克戎变异株引起的学校聚集性疫情

A school cluster outbreak of COVID-19 caused by SARS-CoV-2 Omicron variant

  • 摘要:
      目的  对新冠病毒奥密克戎变异株引起的学校聚集性疫情流行特征进行分析,以期为新冠肺炎疫情防控提供参考依据。
      方法  收集河南省安阳市某寄宿学校新冠病毒感染者流行病学特征、实验室检测结果、学校基本情况等信息,采用频数(构成比)、直方图等描述疫情流行特征,应用R软件计算基本再生系数(R0)和动态再生系数(Rt)。
      结果  2022年1月8 — 19日,该校累计报告283例新冠病毒感染者,罹患率为6.8 %;疫情主要集中在高中部(282例),其次为初中部(1例),涉及23个班级,班级罹患率在1.6 %~76.8 %。学生269例,平均(17.0 ± 0.9)岁,男女比例为1 : 1.09;教师14例,性别以女性为主(占比78.6 %),中位年龄MP25P75)为24.0(23.0,30.0)岁。疫情流行毒株为奥密克戎变异株BA.1分支,R0为5.46(95 % CI = 3.11~8.77),Rt先上升后下降。18.4 %(52/283)的感染者出现临床症状,主要以发热(69.2 %)、咽痛(30.8 %)、咳嗽(19.2 %)为主,临床症状严重程度为轻型和普通型。
      结论  本次疫情奥密克戎变异株传染性强,造成感染人数多,引起临床严重程度轻,后续应加强病例的长期随访,评估青少年人群感染奥密克戎变异株可能存在的长期效应。

     

    Abstract:
      Objective  To analyze a cluster outbreak of coronavirus disease 2019 (COVID-19) caused by the Omicron variant of severe acute respiratory syndrome coronavirus virus 2 (SARS-CoV-2) in a boarding school for providing a reference to COVID-19 epidemic prevention and control.
      Methods  From China Information System for Disease Control and Prevention, we extracted the information on all COVID-19 cases laboratory-confirmed during January 8 – 19, 2022 among the students and teachers in a boarding school at a county in Henan province. Incidence rate (proportion) and histogram were used to describe epidemiological characteristics of the outbreaks. Basic reproduction number (R0) and time-varying reproduction number (Rt) were calculated with R software.
      Results  Totally 283 COVID-19 cases infected with SARS-CoV-2 Omicron BA.1 variant were diagnosed during the 12-day period and the attack rate was 6.8% for the 4 124 students and teachers of the school. The cases occurred in 23 classes (all for senior high school students and only one for junior high school students) and the class-specific attack rate ranged 1.6% – 76.8%. For the 269 student cases at a mean age of 17.0 ± 0.9 years, the male to female ratio was 1 : 1.09; while the mean age was 24.0 (25th percentile = 23.0, 75th percentile = 30.0) years for the 14 teacher cases. The estimated R0 was 5.46 (95% confidence interval: 3.11, 8.77); the estimated Rt increased first and then declined. Obvious symptoms were observed among 18.4% (52) of all cases and major clinical manifestations included fever, sore throat and cough, which occurred in 69.2%, 30.8% and 19.2% of the 52 sufferers. The confirmed cases were clinically classified as common or mild type patients.
      Conclusion  The Omicron variant of SARS-CoV-2 identified among the cases of the school cluster outbreak of COVID-19 was highly contagious but induced relatively mild clinical symptoms. Follow up studies need to be conducted among the cases of the epidemic outbreak to assess long-term adverse effects of the viral infection in the infected people.

     

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