6～18岁双生子BMI遗传度及与青春期关系

郭婷婷; 白云洁; 樊爱平; 范丽丽; 李元成; 陈天娇

doi:10.11847/zgggws1140774

6～18岁双生子BMI遗传度及与青春期关系

BMI heritability and its relationship with puberty in 6 – 18-year-old twins

摘要

摘要:
目的分析山东省6～18岁双生子BMI的遗传度及青春期影响。
方法于2021年11月通过山东省3县区453对6～18岁同性别双生子构建结构方程模型计算BMI遗传度，探究青春期对BMI遗传度的影响及性别差异。
结果调整性别、年龄后6～18岁儿童青少年BMI的遗传度为0.84（95%CI = 0.80～0.88），青春期前期BMI的遗传度为0.81（95%CI = 0.74～0.86），青春期后期BMI的遗传度为0.88（95%CI = 0.81～0.93）；男生和女生青春期前期BMI遗传度分别为0.77（95%CI = 0.67～0.85）和0.85（95%CI = 0.77～0.91），青春期后期分别为0.92（95%CI = 0.82～0.97）和0.86（95%CI = 0.76～0.92）。
结论遗传因素对青春期前后BMI变异具有重要影响，BMI的遗传度在青春期后期增加，且在男生中更为明显。

Abstract:
Objective To analyze the heritability of body mass index (BMI) and the impact of puberty on the heritability among twins aged 6 – 18 years in Shandong province.
Methods Data on 453 pairs of child and adolescent twins of the same sex were collected from three counties/districts of Shandong province in November 2021. Univariate structural equation modeling was used to estimate the heritability of BMI.
Results After adjusting for gender and age, the heritability of BMI in the twins was 0.88 (95% confidence interval 95%CI: 0.80 – 0.88); the heritability of prepubertal BMI was 0.81 (95%CI: 0.74 – 0.86); and the heritability of BMI in late puberty was 0.88 (95%CI: 0.81 – 0.93). The heritability of BMI in prepubertal boys and girls was 0.77 (95%CI: 0.67 – 0.85) and 0.85 (95%CI: 0.77 – 0.91), and 0.92 (95%CI: 0.82 – 0.97) and 0.86 (95%CI: 0.76 – 0.92) in late puberty, respectively.
Conclusion Genetic factors appear to play an important role in explaining the variation of BMI from prepuberty to late puberty, particularly in boys.

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