Abstract: The study explored the association between hypertension and ploymorphism of the ACE gene in Yi and Han people with the cross-sectional survey and PCR technique.Among the male Yi people,the distribution of DD,ID and Ⅱ genotypes for the ACE gene was 9.7% and 13.0%,48.4% and 50.9%,41.9% and 36.1%,respectively,in hyper tensives and normotensives.Frequencies of I and Dalleles for the ACE gene were 6611%and 61.6%,33.9% and 38.4%,respectively,in hypertensives and normotensives.Among the male Han people,the distribution of DD,ID and II genotypes for the ACE gene was 12.3% and 11.2%,50.8% and 49.5%,36.9% and 39.3%,respectively,in hyper tensives and nor motensives.Frequencies of I and D alleles for the ACE gene were 62.3% and 64.0%,37.7% and 36.0%,respectively,in hypertensives and normotensives.There were no significant difference in the distribution of Ⅱ,ID and DD genotypes and the frequencies of I/D alleles for the ACE gene between hypertensives and nor motensives in the male Yi and Han people.The association between polymorphism of the ACE gene and hypertension was uncertainty among the studied population.