Abstract: According to statistical data,among the Iegally reported infectious diseases,except Plaguem,Anthrax,Brucellosis and Kala-azar,the other kinds of them were in the list,and Lung Teberculosis,Gonorrhea,Viral Hepatitis,Dysentery and Syphilis had a high-incidence in Shenzhen during 1980～1997 The incidence and mortality curves of total acute infectious disease showed declining In the rank order of infectious diseases,the rank of EPI target diseases were going down and that of intestinal infectious diseases going up These indicate that we should reinforce the management of intestinal infectious diseases,especially Cholera surveillance and viral hepatitis control.