Abstract: To investigate the changes in concentration of trace elements and antioridase in serum and inheritance factors in Schizophrenic patients.The concentration of Cu,Zn trace elements and SOD GSH-Px in Schizophrenic patients,first-degree relatives and healthy volunteers were detected by RIA and isoionic illuminating assay.The results showed that the concentration of the serum SOD in Schizophrenic patient was significantly higher than that in healthy volunteers(P<0.01).No significant difference was found among the first-degree relatives,healthy volunteers and Schizophrenic-patients.The activity of GSH-Px was much lower than that in healthy volunteers and first-degree relatives (P<0.01),while there was no significant difference between first-degree relatives and healthy volunteers.The levels of Cu, Zn in Schizophrenic patients and first-degree relatives were significantly lower than that in healthy volunteers(P<0.05).The results indicate that the lower concentration of Cu,Zn leading to the changes of SOD and GSH-Px may play some roles in the pathogenesis of schizophrenia with the genetic factors.