Abstract: In order to clarify the routes of transmission of hemorrhagic fever with renal syndrome(HFRS),we carried out a series of studies on the relationship between gamasid mites,chigger mites and HFRS.The results show that gamasid mites and chigger mites were the dominant species in litters of A podem us agrarius the main reservoir of HFRS,their seasonal distribution were correlated with the incidence of human HFRS,they could pierce the normal skin of rodent and human to suck blood,those two mites could naturally be infected by HFRS viras,HFRS virus could be transmitted through the bite of mites among rodents and through transovarial transmission in mites.The antigenicity of HFRS virus isolated from mice and mites were identical.The results indicated that those two mites can serve as transmitting vector of field rodent type of HFRS and act as a reservoir host as well.